Langerhans cell histiocytosis masquerading as tuberculosis: a diagnostic dilemma resulting in inappropriate anti-tubercular therapy

Pediatric Blood & Cancer
Prashant SharmaTejinder Singh

Abstract

Langerhans cell histiocytosis is known to mimic many other conditions. We present two patients where anti-tubercular therapy was instituted when clinical and radiological features suggested tuberculosis. The correct diagnosis of histiocytosis was reached only on further work-up including immunohistochemistry following un-responsiveness to treatment. In retrospect it was felt that an inordinately high index of suspicion for tuberculosis, clinical and radiological overlap between the two entities, an urgency to start empirical therapy in a rapidly deteriorating patient and pathological similarities between epithelioid histiocytes and pathologic Langerhans cells led to the diagnostic and therapeutic errors.

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Citations

Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rama Kumari BadyalNeelam Varma
Nov 2, 2011·Annals of Tropical Paediatrics·M P SenanayakeM V C De Silva
Dec 12, 2012·Journal of Paediatrics and Child Health·Wan-Yee TeoMei-Yoke Chan
Apr 29, 2015·Tropical Doctor·Latha Magatha SnehaJulius Xavier Scott

Related Concepts

Antitubercular Agents
Differential Diagnosis
Misdiagnosis
Hashimoto-Pritzger Disease
Tuberculosis, Pulmonary
Diagnosis
Histiocytes
Histiocytosis
Histiocytosis, Langerhans-Cell
Immunohistochemistry

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