Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France - 10th-11th centuries AD)

Antony ColomboOlivier Dutour


In 2008, a skeleton of a 1 - 2.5-year-old child radiocarbon dated from the 10th - 11th century AD was discovered on the oppidum of La Granède (Millau, France). It presents multiple cranial osteolytic lesions having punched-out or geographical map-like aspects associated with sequestrum and costal osteitis. A multi 3D digital approach (CT, μCT and virtual reconstruction) enabled us to refine the description and identify the diploic origin of the lytic process. Furthermore, precise observation of the extent of the lesions and associated reorganization of the skeletal micro-structure were possible. From these convergent pieces of evidence, the differential diagnosis led to three possibilities: Langerhans cell histiocytosis, tuberculosis, or Langerhans cell histiocytosis and tuberculosis.


Jul 1, 1992·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M A StullK O Devaney
Aug 1, 1984·The Journal of Pediatrics·J D SchusterQ T Box
Jul 1, 1982·American Journal of Physical Anthropology·J B GreggW M Bass
Jan 1, 1980·Medical and Pediatric Oncology·D M KompS L George
Aug 15, 2001·Journal of Cancer Research and Clinical Oncology·M WüllingE Kaiser
Jul 13, 2002·American Journal of Physical Anthropology·Israel HershkovitzBruce M Rothschild
Nov 1, 1963·Journal of Dental Research·C F MoorreesE E Hunt
Jun 1, 1963·American Journal of Physical Anthropology·C F MoorreesE E Hunt
Aug 4, 2004·Pediatric Radiology·E Michel AzouzAntonello Podda
Sep 13, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joshua BurrillRakesh R Misra
Oct 2, 2007·American Journal of Clinical Dermatology·Sigrid M C BroekaertMartin Schaller
Sep 26, 2009·International Journal of Hematology·Shinsaku ImashukuJapan LCH Study Group
Jun 24, 2010·Skeletal Radiology·Félicie JenninJean-Denis Laredo
Feb 9, 2011·American Journal of Physical Anthropology·E L N Conceição, H F V Cardoso
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandra Krishnan
Nov 2, 2011·Annals of Tropical Paediatrics·M P SenanayakeM V C De Silva

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Differential Diagnosis
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