Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France - 10th-11th centuries AD)

Tuberculosis
Antony ColomboOlivier Dutour

Abstract

In 2008, a skeleton of a 1 - 2.5-year-old child radiocarbon dated from the 10th - 11th century AD was discovered on the oppidum of La Granède (Millau, France). It presents multiple cranial osteolytic lesions having punched-out or geographical map-like aspects associated with sequestrum and costal osteitis. A multi 3D digital approach (CT, μCT and virtual reconstruction) enabled us to refine the description and identify the diploic origin of the lytic process. Furthermore, precise observation of the extent of the lesions and associated reorganization of the skeletal micro-structure were possible. From these convergent pieces of evidence, the differential diagnosis led to three possibilities: Langerhans cell histiocytosis, tuberculosis, or Langerhans cell histiocytosis and tuberculosis.

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Related Concepts

Differential Diagnosis
Hashimoto-Pritzger Disease
Optical Image Reconstruction
Paleopathology
Tuberculosis, Osteoarticular
Imaging, Three-Dimensional, Computer Assisted
History of Medicine, Renaissance
Alzheimer's Disease
Differential Diagnosis
Histiocytosis, Langerhans-Cell

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