Langerhans cells express matrix metalloproteinases 9 and 2 and tissue inhibitors of metalloproteinases 1 and 2 in healthy human gingival tissue and in periodontitis

Oral Microbiology and Immunology
Agnès BodineauSylvie Séguier

Abstract

As antigen-presenting cells, Langerhans cells may play an important role in the initiation and maintenance of periodontal disease. This study is the first report that extends our knowledge of the expression of matrix metalloproteinases and their endogenous tissue inhibitors by Langerhans cells in healthy and diseased gingival tissues. Single and double immunolabeling procedures were carried out using monoclonal antibodies against CD1a, matrix metalloproteinases 2 and 9, and tissue inhibitors of matrix metalloproteinases 1 and 2, and analyzed by conventional and confocal microscopes. Langerhans cells expressed matrix metalloproteinases 2 and 9, and tissue inhibitors of matrix metalloproteinases 1 and 2 in healthy and diseased gingival tissues. The tissue inhibitors of matrix metalloproteinase-positive Langerhans cells were mainly observed in the upper epithelial layers. Matrix metalloproteinase 9-positive Langerhans cells were observed especially during periodontitis and in the basal epithelial layer or crossing the basement membrane. During periodontal disease, changes in the expression of matrix metalloproteinases and their tissue inhibitors by gingival Langerhans cells could be implicated in the migration of the cells towards...Continue Reading

References

Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·F Willenbrock, G Murphy
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A W BarrettD M Williams
Jun 1, 1997·Periodontology 2000·J J Reynolds, M C Meikle
Sep 1, 1999·The British Journal of Dermatology·M CumberbatchI Kimber
Dec 10, 1999·Journal of Periodontology·S SéguierN Brousse
Jun 23, 2000·Annals of Periodontology·G C Armitage
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R JotwaniC W Cutler
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun RatzingerNikolaus Romani
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS

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Citations

Jun 13, 2013·Mucosal Immunology·A-H Hovav
Feb 26, 2011·Journal of Clinical Periodontology·Tord BerglundhMauro Donati
Nov 27, 2008·Brazilian Dental Journal·Ruthinéia Diógenes Alves Uchôa LinsRoseana de Almeida Freitas

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