Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kathryn J FarrandIan F Hermans

Abstract

Distinct dendritic cell (DC) subsets differ with respect to pathways of Ag uptake and intracellular routing to MHC class I or MHC class II molecules. Murine studies suggest a specialized role for CD8alpha(+) DC in cross-presentation, where exogenous Ags are presented on MHC class I molecules to CD8(+) T cells, while CD8alpha(-) DC are more likely to present extracellular Ags on MHC class II molecules to CD4(+) T cells. As a proportion of CD8alpha(+) DC have been shown to express langerin (CD207), we investigated the role of langerin(+)CD8alpha(+) DC in presenting Ag and priming T cell responses to soluble Ags. When splenic DC populations were sorted from animals administered protein i.v., the ability to cross-present Ag was restricted to the langerin(+) compartment of the CD8alpha(+) DC population. The langerin(+)CD8alpha(+) DC population was also susceptible to depletion following administration of cytochrome c, which is known to trigger apoptosis if diverted to the cytosol. Cross-priming of CTL in the presence of the adjuvant activity of the TLR2 ligand N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-[R]-Cys-[S]-Serl-[S]-Lys4-trihydrochloride or the invariant NKT cell ligand alpha-galactosylceramide was severely impaired i...Continue Reading

References

Jul 17, 1995·Journal of Immunological Methods·A D McLellanD N Hart
Jan 14, 1994·Cell·K A HogquistF R Carbone
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P KalińskiM L Kapsenberg
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H HochreinM O'Keeffe
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny ValladeauSem Saeland
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Stewart Shuman
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Mar 1, 2003·Science·E Sergio TrombettaIra Mellman
Mar 11, 2003·Glycobiology·Nicola S Stambach, Maureen E Taylor
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian F HermansVincenzo Cerundolo
Jul 6, 2004·Immunological Reviews·William R HeathJose A Villadangos
Dec 17, 2004·Molecular and Cellular Biology·Adrien KissenpfennigPatrice Douillard
Jan 5, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Kudakwashe Chikwava, Ronald Jaffe
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·John SchmiegMoriya Tsuji
Mar 18, 2005·Annual Review of Immunology·E Sergio Trombetta, Ira Mellman
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun-Sang J SungSteven R Beaty
Jun 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Petra SchnorrerJose A Villadangos
Jul 11, 2006·Immunological Reviews·Vladimir P Badovinac, John T Harty
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert W CarterDavid F Tough
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Jan 6, 2007·Science·Diana DudziakMichel C Nussenzweig
Jun 26, 2007·Nature Reviews. Immunology·José A Villadangos, Petra Schnorrer
Dec 19, 2007·The Journal of Experimental Medicine·Laura S BurschKristin A Hogquist

❮ Previous
Next ❯

Citations

Oct 12, 2012·Seminars in Immunopathology·Photini Sinnis, Fidel Zavala
Feb 8, 2011·Cancer Metastasis Reviews·Yuting MaLaurence Zitvogel
Mar 17, 2010·Immunology and Cell Biology·Botond Z Igyarto, Daniel H Kaplan
Apr 7, 2010·Immunology and Cell Biology·Nikolaus RomaniVincent Flacher
Oct 6, 2014·Nature Chemical Biology·Regan J AndersonIan F Hermans
Mar 15, 2016·Immunotherapy·Cameron S FieldMartin K Hunn
Jun 5, 2015·Frontiers in Immunology·Soledad Mac KeonRosa Wainstok
Feb 22, 2014·Journal of Immunological Methods·Kelly A PrendergastJoanna R Kirman
Mar 24, 2017·Scientific Reports·Zoran V PopovicHermann-Josef Gröne
Oct 26, 2011·Nature Reviews. Immunology·Andrew ChowMiriam Merad
Apr 19, 2013·Diagnostic Cytopathology·Anthony Henwood
Nov 20, 2010·Nature Reviews. Immunology·Shannon J TurleyKutlu G Elpek
Mar 17, 2010·Immunology and Cell Biology·Sandrine HenriBernard Malissen
Mar 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Priyanka SatheKen Shortman
Jun 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taryn L OsmondIan F Hermans
Jan 11, 2020·Frontiers in Immunology·Cristiana F PiresCarlos-Filipe Pereira
Dec 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angelika StoecklingerPeter Hammerl
Feb 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincent FlacherNikolaus Romani
Jun 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irah L KingElizabeth A Leadbetter
Jun 11, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elodie Macho-FernandezChristelle Faveeuw
Mar 7, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li BaiAlbert Bendelac
Jan 5, 2013·Clinical and Experimental Immunology·D G HancockB Fazekas de St Groth
Aug 27, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah C Saunderson, Alexander D McLellan
Apr 30, 2019·Frontiers in Immunology·Ronald A BackerBjörn E Clausen
May 6, 2019·Cancer Immunology Research·Pui Yeng LamStephen R Mattarollo
Nov 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin K HunnIan F Hermans
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Meng FengWei Lin
Feb 18, 2018·Current Opinion in Virology·Anita K McElroyCésar Muñoz-Fontela
Apr 7, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manfred B LutzBjörn E Clausen
Apr 14, 2021·Immunology Letters·Lukas HatscherDiana Dudziak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.