Language comprehension and regional cerebral defects in frontotemporal degeneration and Alzheimer's disease

Neurology
Murray GrossmanA Alavi

Abstract

We related profiles of language comprehension difficulty to patterns of reduced cerebral functioning obtained with high-resolution single photon emission computed tomography (SPECT) in patients with neurodegenerative conditions. We found different patterns of reduced relative cerebral perfusion in patients with frontotemporal degeneration (FD) and patients with Alzheimer's disease (AD). Cognitive assessments also showed different patterns of impaired comprehension in patients with FD and patients with AD. Grammatical comprehension difficulty in FD correlated with relative cerebral perfusion in left frontal and anterior temporal brain regions; impaired semantic processing in AD correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere. These findings are consistent with the hypothesis that a neural network distributed throughout the left hemisphere subserving different aspects of language comprehension, rather than a single brain region, is responsible for understanding language.

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Citations

Mar 4, 1998·Annals of Neurology·A P LiebermanM Grossman
Apr 12, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Takao KubotaTsunehiko Nishimura
May 9, 2003·Brain and Language·Ayanna CookeMurray Grossman
Jun 26, 2008·Journal of the International Neuropsychological Society : JINS·Tania GiovannettiDavid J Libon
May 1, 2009·Journal of the International Neuropsychological Society : JINS·John ListerudMurray Grossman
Dec 20, 2007·Alzheimer Disease and Associated Disorders·Jennifer M OgarMaria Luisa Gorno-Tempini
Feb 1, 2007·Neuropsychiatric Disease and Treatment·Hervé AllainDanièle Bentué-Ferrer
Sep 7, 2012·CNS Drugs·Rachel E Seltman, Brandy R Matthews
Jan 16, 2014·Cognitive, Affective & Behavioral Neuroscience·Jonathan E PeelleMurray Grossman
Jun 24, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Daniela SammlerAngela D Friederici
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
Jan 18, 2006·Brain Research Reviews·Armin von GuntenPatrick R Hof
Aug 5, 2000·Brain and Language·K NobleM Grossman
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Marianne ChapleauSimona M Brambati
Mar 27, 2007·Journal of Cognitive Neuroscience·Perrine RubyEric Salmon
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