Language-induced epilepsy, acquired stuttering, and idiopathic generalized epilepsy: phenotypic study of one family

Epilepsia
Maria Paola ValentiEdouard Hirsch

Abstract

Language-induced epilepsy involves seizure precipitation by speaking, reading, and writing. Seizures are similar to those of reading epilepsy (RE). The nosologic position of language-induced epilepsy is not clear. We performed a clinical and neurophysiological study in a multigenerational family with the association of idiopathic generalized epilepsy (IGE) with ictal stuttering as a manifestation of reflex language-induced epilepsy. Nine members on three generations were studied. All patients underwent video-polygraphic EEG recordings (awake and during sleep). A standardized protocol was applied to test the effect of language and non-language-related tasks. Six patients presented language-induced jaw jerking that mimicked stuttering and corresponded to focal myoclonus involving facial muscles. This was associated with an IGE phenotype in four of these patients. Focal EEG spikes were found in all six patients by visual analysis and/or back-averaging techniques. The focal spikes were either asymptomatic (when followed by a slow wave) or symptomatic of facial myoclonia (when isolated). Levetiracetam, used as add-on or monotherapy in four patients, suppressed ictal stuttering. One additional case only had a phenotype of IGE without...Continue Reading

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Citations

Feb 15, 2016·Epilepsy Research·Domenico ItalianoEdoardo Ferlazzo
Jun 17, 2015·Seizure : the Journal of the British Epilepsy Association·Dorothée G A Kasteleijn-Nolst TrenitéBobby P C Koeleman
Apr 29, 2014·Seizure : the Journal of the British Epilepsy Association·Domenico ItalianoUmberto Aguglia
Jul 29, 2015·Seizure : the Journal of the British Epilepsy Association·Elza Márcia Yacubian, Peter Wolf

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