Language phenotypes in children with sex chromosome trisomies.

Wellcome Open Research
Dorothy V M BishopPaul A Thompson

Abstract

Background Sex chromosome trisomies (47,XXX, 47,XXY and 47,XYY) are known to be a risk factor for language disorder, but it is hard to predict outcomes, because many cases are identified only when problems are found. Methods We recruited children aged 5-16 years with all three types of trisomy, and divided them into a High Bias group, identified in the course of investigations for neurodevelopmental problems, and a Low Bias group, identified via prenatal screening or other medical investigations. Children from a twin sample were used to compare pattern and severity of language problems: they were subdivided according to parental concerns about language/history of speech-language therapy into a No Concerns group (N = 118) and a Language Concerns group (N = 57). Children were assessed on a psychometric battery and a standardized parent checklist. After excluding children with intellectual disability, autism or hearing problems, the sample included 28 XXX, 18 XXY and 14 XYY Low Bias cases and 7 XXX, 13 XXY and 17 XYY High Bias cases. Results Variation within each trisomy group was substantial: within the Low Bias group, overall language scores were depressed relative to normative data, but around one third had no evidence of probl...Continue Reading

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Citations

May 21, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Joachim WistubaJörg Gromoll
Jun 4, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Morten Muhlig NielsenClaus Højbjerg Gravholt
Jun 18, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kristen WigbyNicole Tartaglia
Sep 6, 2019·Wellcome Open Research·Alexander C WilsonDorothy V M Bishop
May 27, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Hayley S MountfordDianne F Newbury
Mar 18, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kirsten A RigganMegan A Allyse
May 19, 2020·Developmental Neurorehabilitation·Puck Christine van ElstCaroline Junge
Mar 17, 2021·Journal of Genetic Counseling·Kirsten A RigganMegan A Allyse
Apr 1, 2021·Expert Review of Molecular Diagnostics·Cechuan DengHongqian Liu
Aug 5, 2021·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Evelien UrbanusSophie van Rijn
Nov 26, 2021·Journal of Neuroscience Research·Anna Maria ChilosiClaudia Casalini
Dec 16, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Agnethe BerglundClaus Højbjerg Gravholt

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Methods Mentioned

BETA
environmental stress

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