Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase

Phytochemistry
Xian-Qiang ChenShao-Ping Li

Abstract

Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z3, 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.

Citations

May 10, 2020·Animals : an Open Access Journal From MDPI·Wen Yang ChuangTzu-Tai Lee
Jun 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xian-Qiang ChenShao-Ping Li
Jun 18, 2019·Journal of the Science of Food and Agriculture·Mengting NiGuowen Zhang
Dec 27, 2018·Journal of Asian Natural Products Research·Lai-Bin ZhangJie-Li Lv
Nov 23, 2019·Journal of Asian Natural Products Research·Qiaofen YangMin Zhou
Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
Jan 21, 2021·Journal of Fungi·Jelena Aramabašić JovanovićMelita Vidaković

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