Lanosterol synthase in dicotyledonous plants

Plant & Cell Physiology
Masashi SuzukiY Ebizuka

Abstract

Sterols are important as structural components of plasma membranes and precursors of steroidal hormones in both animals and plants. Plant sterols show a wide structural variety and significant structural differences from those of animals. To elucidate the origin of structural diversity in plant sterols, their biosynthesis has been extensively studied [Benveniste (2004) Annu. Rev. Plant. Biol. 55: 429, Schaller (2004) Plant Physiol. Biochem. 42: 465]. The differences in the biosynthesis of sterols between plants and animals begin at the step of cyclization of 2,3-oxidosqualene, which is cyclized to lanosterol in animals and to cycloartenol in plants. However, here we show that plants also have the ability to synthesize lanosterol directly from 2,3-oxidosqualene, which may lead to a new pathway to plant sterols. The Arabidopsis gene At3g45130, designated LAS1, encodes a functional lanosterol synthase in plants. A phylogenetic tree showed that LAS1 belongs to the previously uncharacterized branch of oxidosqualene cyclases, which differs from the cycloartenol synthase branch. Panax PNZ on the same branch was also shown to be a lanosterol synthase in a yeast heterologous expression system. The higher diversity of plant sterols may r...Continue Reading

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Citations

Feb 4, 2012·The Arabidopsis Book·Steven D Clouse
Mar 30, 2007·Lipids·Masashi Suzuki, Toshiya Muranaka
Nov 23, 2007·Natural Product Reports·Ikuro Abe
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elena BabiychukHubert Schaller
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kiyoshi OhyamaToshiya Muranaka
Feb 7, 2014·Annual Review of Plant Biology·Ramesha ThimmappaAnne Osbourn
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Sep 10, 2011·Chemical Reviews·W David Nes
Nov 4, 2008·Plant Physiology and Biochemistry : PPB·Masaaki ShibuyaYutaka Ebizuka
Jun 19, 2008·Plant Biology·Y Liang, S Zhao
Aug 14, 2012·The Plant Journal : for Cell and Molecular Biology·Young S GoMi C Suh
Dec 14, 2011·The New Phytologist·Zheyong XueXiaoquan Qi
Mar 10, 2015·Biotechnology Advances·Yu-Jin KimDeok-Chun Yang
Apr 24, 2012·Journal of Lipids·Naïm Stiti, Marie-Andrée Hartmann
Jun 3, 2015·Lipids·Elisabet Gas-PascualThomas J Bach
Aug 26, 2009·Plant Signaling & Behavior·Elena BabiychukHubert Schaller
Dec 23, 2016·Nature Plants·Thomas J Bach
Oct 21, 2018·The Plant Journal : for Cell and Molecular Biology·Yi Shang, Sanwen Huang
Mar 20, 2019·Scientific Reports·Edith ForestierHubert Schaller
Aug 31, 2019·Phytochemical Analysis : PCA·Mohammad MohammadiDavar Abedini
Mar 17, 2020·Annual Review of Plant Biology·Joseph R Jacobowitz, Jing-Ke Weng
Feb 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing QiaoXiaojun Ma

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