Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review

Heart Failure Reviews
Nonhlakanipho F SangweniRabia Johnson

Abstract

The epidemic of cardiovascular diseases is a global phenomenon that is exaggerated by the growing prevalence of diabetes mellitus. Coronary artery disease and diabetic cardiomyopathy are the major cardiovascular complications responsible for exacerbated myocardial infarction in diabetic individuals. Increasing research has identified hyperglycemia and hyperlipidemia as key factors driving the augmentation of oxidative stress and a pro-inflammatory response that usually results in increased fibrosis and reduced cardiac efficiency. While current antidiabetic agents remain active in attenuating diabetes-associated complications, overtime, their efficacy proves limited in protecting the hearts of diabetic individuals. This has led to a considerable increase in the number of natural products that are screened for their antidiabetic and cardioprotective properties. These natural products may present essential ameliorative properties relevant to their use as a monotherapy or as an adjunct to current drug agents in combating diabetes and its associated cardiovascular complications. Recent findings have suggested that triterpenes isolated from Protorhus longifolia (Benrh.) Engl., a plant species endemic to Southern Africa, display stron...Continue Reading

References

Mar 1, 1990·International Journal of Cardiology·G NigroR J Bain
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Jun 1, 1997·Journal of Natural Products·M ManickamA B Ray
Apr 10, 2002·Circulation·Heinrich TaegtmeyerMartin E Young
Feb 18, 2004·The Journal of Biological Chemistry·Jing AnZiwei Huang
Apr 6, 2006·Cardiovascular Diabetology·Rajprasad LoganathanIrina V Smirnova
Jul 11, 2006·The Journal of Clinical Investigation·Yun Chau Long, Juleen R Zierath
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Apr 4, 2008·European Journal of Pharmacology·Ru ZhouGuidong Dai
Jul 17, 2008·Vascular Health and Risk Management·Andre Pascal KengneEugene Sobngwi
Nov 15, 2008·Journal of Molecular and Cellular Cardiology·Xiaoqing HeQiang Ma
May 28, 2009·Journal of Lipid Research·Raffaele MarfellaGiuseppe Paolisso
Jun 6, 2009·QJM : Monthly Journal of the Association of Physicians·M Miller
Jun 13, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Kaivan KhavandiRayaz A Malik
Dec 18, 2009·Current Medicinal Chemistry·E AdeghateK Teke
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Feb 25, 2010·Reviews in Endocrine & Metabolic Disorders·Sihem Boudina, Evan Dale Abel
Apr 27, 2010·Veterinary Pathology·R S SellersN K Khan
Jan 29, 2011·Drug Discovery Today. Disease Mechanisms·Pavan K BattiproluJoseph A Hill
Feb 4, 2011·Cardiovascular Research·Vincenzo LionettiFabio A Recchia
Jun 28, 2011·The New England Journal of Medicine·Pablo E PergolaUNKNOWN BEAM Study Investigators
Jun 14, 2012·Journal of General Internal Medicine·Hermes FlorezUNKNOWN Diabetes Prevention Program Research Group
Sep 27, 2012·The Journal of Pathology·David M Ansley, Baohua Wang
Oct 4, 2012·Journal of Molecular and Cellular Cardiology·Ju-Yun TsaiMartin E Young
Feb 19, 2013·Diabetology & Metabolic Syndrome·Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes
Nov 26, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiao SunXiao-bo Sun
Jan 7, 2014·Journal of Molecular and Cellular Cardiology·Ying YangZhenlong Wu
Jan 31, 2014·Diabetologia·Heiko Bugger, E Dale Abel
Mar 1, 2014·Journal of Cardiac Failure·Sanjay DandamudiHorng H Chen
Jul 25, 2014·Annals of Clinical Microbiology and Antimicrobials·Dambudzo PendukaAndy Opoku
Jul 30, 2014·Journal of Bioenergetics and Biomembranes·Figen Amber CicekBelma Turan
Aug 6, 2014·Cardiology Clinics·Doron Aronson, Elazer R Edelman
Aug 17, 2014·Lipids in Health and Disease·Kgothatso E MachabaAndy R Opoku
Sep 23, 2014·Cell Death and Differentiation·L GalluzziG Kroemer

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Saeed SamarghandianFariborz Samini
Asian Pacific Journal of Tropical Medicine
Tahereh FarkhondehAbasalt Borji
International Journal of Molecular Sciences
Yosuke KayamaPhilip S Tsao
American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Phiwayinkosi V DludlaBongani B Nkambule
© 2022 Meta ULC. All rights reserved