PMID: 8968456Dec 1, 1996Paper

Lansoprazole: a proton pump inhibitor

The Annals of Pharmacotherapy
W R Garnett

Abstract

To summarize the published data on lansoprazole, a proton pump inhibitor approved by the Food and Drug Administration for use in the treatment of duodenal ulcer, erosive esophagitis, and pathologic hypersecretory conditions (e.g., Zollinger-Ellison syndrome). Published data on lansoprazole identified by MEDLINE searches (1985-1996), as well as other pertinent literature. Clinical efficacy trials discussed were limited to multicenter, double-blind, parallel group, prospective studies, where possible. Lansoprazole inhibits gastric acid secretion via inhibition of gastric hydrogen/potassium adenosine triphosphatase (H+,K(+)-ATPase), an enzyme of the gastric parietal cell membrane that forms part of the proton pump that performs the final step in the acid secretory process. Lansoprazole binds covalently to parietal cell H+,K(+)-ATPase, rendering it nonfunctional and inhibiting the secretion of gastric acid. In clinical trials, lansoprazole has been shown to be more effective than placebo and standard doses of histamine (H)2-receptor antagonists and as effective as standard doses of omeprazole for the treatment of peptic ulcer disease, gastroesophageal reflux, Zollinger-Ellison syndrome, and nonsteroidal antiinflammatory drug-induce...Continue Reading

Citations

Aug 31, 2020·Dose-response : a Publication of International Hormesis Society·Ayesha NaveedMuhammad Irfan
Jan 17, 2003·The Journal of Biological Chemistry·Kaushik BiswasRanajit K Banerjee
Aug 31, 2004·World Journal of Gastroenterology : WJG·Hiroshi IchikawaToshikazu Yoshikawa
Apr 28, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Dan ZhangHuichen Liu
Dec 19, 2003·Journal of Clinical Pharmacology·Kyung-Sang YuByoung-Seok Moon
Aug 26, 2010·The American Journal of Gastroenterology·Philipp KirchhoffJohn P Geibel

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