Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats

World Journal of Gastroenterology : WJG
Hiroshi IchikawaToshikazu Yoshikawa

Abstract

To investigate the protective effect of lansoprazole on ischemia and reperfusion (I/R)-induced rat intestinal mucosal injury in vivo. Intestinal damage was induced by clamping both the superior mesenteric artery and the celiac trunk for 30 min followed by reperfusion in male Sprague-Dawley rats. Lansoprazole was given to rats intraperitoneally 1 h before vascular clamping. Both the intraluminal hemoglobin and protein levels, as indices of mucosal damage, significantly increased in I/R-groups comparison with those of sham-operation groups. These increases in intraluminal hemoglobin and protein levels were significantly inhibited by the treatment with lansoprazole at a dose of 1 mg/kg. Small intestine exposed to I/R resulted in mucosal inflammation that was characterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associated myeloperoxidase activity (MPO), and mucosal content of rat cytokine-induced neutrophil chemoattractant-1 (CINC-1). These increases in TBARS, MPO activities and CINC-1 content in the intestinal mucosa after I/R were all inhibited by pretreatment with lansoprazole at a dose of 1 mg/kg. Furthermore, the CINC-1 mRNA expression was increased during intestinal I/R, and this i...Continue Reading

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Citations

Oct 2, 2009·Journal of Clinical Biochemistry and Nutrition·Kazuhide HiguchiEiji Umegaki
Dec 8, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Cristina PozzoliGabriella Coruzzi
Jan 15, 2008·Journal of Clinical Biochemistry and Nutrition·Yuji Naito
Aug 29, 2009·Digestive Diseases and Sciences·Ramalinga R KedikaStuart Jon Spechler
Mar 23, 2017·International Heart Journal·Wengen Zhu, Kui Hong
Feb 6, 2019·Fundamental & Clinical Pharmacology·Parichehr KohansalHamed Shafaroodi
Apr 17, 2008·Scandinavian Journal of Gastroenterology·Yoichi SaegusaKazuhiko Ishihara
Apr 26, 2008·Journal of Clinical Biochemistry and Nutrition·Norimasa Yoshida
Oct 18, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Rupinder KaurUpendra K Jain

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