PMID: 8971302Dec 1, 1996Paper

Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection

Alimentary Pharmacology & Therapeutics
A W HarrisJ J Misiewicz

Abstract

This study determines the efficacy and safety of a 1-week triple therapy regimen of lansoprazole, clarithromycin and metronidazole in an area with a high prevalence of pre-treatment metronidazole-resistant strains of Helicobacter pylori. Seventy-five H. pylori positive patients with gastritis or duodenal ulcer were entered into an open study of lansoprazole 30 mg o.m., clarithromycin 250 mg b.d. and metronidazole 400 mg b.d. H. pylori status was determined by CLOtest, histology, culture and by 13C-urea breath test (repeated > or = 28 days after treatment). Seventy-one patients completed the treatment and returned for follow-up. H. pylori was eradicated in 61 of 71 (86%) patients by per-protocol analysis, and in 61 of 75 (81%) patients by intention-to-treat analysis. H. pylori was eradicated in 12 of 16 (75%) patients with metronidazole-resistant strains compared with 22 of 24 (92%) in patients with metronidazole-sensitive strains of H. pylori (P = 0.14). Fourty-five patients reported at least one adverse event, and three patients stopped treatment due to them (two with headaches and one with diarrhoea). A 1-week course of lansoprazole 30 mg o.m., clarithromycin 250 mg b.d. and metronidazole 400 mg b.d. eradicates H. pylori in u...Continue Reading

Citations

Nov 2, 2006·Digestive Diseases and Sciences·Jacob YahavHaim Shmuely
Jul 2, 1999·International Journal of Antimicrobial Agents·T AlarcónM López-Brea
Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F BazzoliR M Zagari
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·G A PipkinJ R Wood
Mar 29, 2000·Alimentary Pharmacology & Therapeutics·F S LehmannC Beglinger
Aug 24, 1999·Gut·J Q Huang, R H Hunt
Feb 20, 2002·British Journal of Clinical Pharmacology·F A Al-EidanJ B McConnell
Oct 8, 2016·Scientific Reports·Nikhil KumarJulie C Dunning Hotopp
Dec 1, 1996·Gut·A Harris, J J Misiewicz
Feb 25, 2014·Nature Genetics·Christina WarinnerEnrico Cappellini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.