Lansoprazole for long-term maintenance therapy of erosive esophagitis: double-blind comparison with ranitidine.

Digestive Diseases and Sciences
D A PeuraS N Atkinson

Abstract

In a study evaluating the efficacy and safety of lansoprazole to prevent the relapse of erosive esophagitis (EE), 206 of 241 patients (85%) healed after open-label treatment with lansoprazole 30 mg once daily for 8 weeks and received double-blind maintenance treatment with lansoprazole 15 mg once daily or ranitidine 150 mg twice daily for up to 1 year. At 1 year, 67% of lansoprazole-treated and 13% of ranitidine-treated patients remained healed (P<0.001). Lansoprazole-treated patients experienced significantly greater symptom relief (P<0.001), and, if asymptomatic at entry into the maintenance phase, remained asymptomatic for significantly longer than ranitidine-treated patients (P<0.001). Symptom status correlated with healing (P=0.001), supporting the symptom-directed management of EE. Both treatments were well tolerated and no unexpected events occurred. Daily therapy with lansoprazole to prevent the relapse of EE is effective, well tolerated, and superior to ranitidine in the maintenance of healing and symptom relief.

References

Aug 1, 1996·Alimentary Pharmacology & Therapeutics·A L GoughC H Langworthy
May 16, 2002·Drugs·James W FrestonE David Ballard
Jun 6, 2003·Alimentary Pharmacology & Therapeutics·A PilottoUNKNOWN Ageing and Acid-Related Disease Study Group
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nimish B VakilDouglas Levine
Sep 2, 2004·Alimentary Pharmacology & Therapeutics·J E RichterUNKNOWN Pantoprazole US GERD Study Group
Sep 24, 2004·Alimentary Pharmacology & Therapeutics·A RuigómezJ Dent
Dec 4, 2004·Alimentary Pharmacology & Therapeutics·B C Delaney
Dec 4, 2004·Alimentary Pharmacology & Therapeutics·G HoltmannT Liebregts
Apr 23, 2005·The Cochrane Database of Systematic Reviews·C DonnellanP Moayyedi
May 10, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kenneth R DevaultMark B Sostek
Jun 27, 2006·Lancet·Paul Moayyedi, Nicholas J Talley
Oct 14, 2006·Journal of the American Geriatrics Society·Alberto PilottoFrancesco Di Mario
Sep 1, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K R DeVaultD C Metz

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