Lansoprazole-induced improvement of esophageal submucosal injury

Journal of Clinical Biochemistry and Nutrition
Shinichiro Mine, Yoshiya Tanaka

Abstract

The proton pumpvinhibitor, lansoprazole, is reported to have acid secretion inhibiting effect as well as anti-inflammatory effects such as inhibition of cytokine secretion from inflammatory cells. Clinically, excellent efficacy of lansoprazole is reported for not only gastric ulcer but also gastroesophageal reflux disease (GERD). Since GERD is categorized endoscopically into erosive esophagitis and non-erosive reflux disease, it is important to make accurate assessment of any improvement in the inflammatory process when using endoscopic ultrasonography (EUS) capable of visualizing the submucosal structure. We report here our experience in assessing the effect of treatment with lansoprazole on esophageal wall structure using EUS in patients with GERD. At baseline (before treatment), EUS showed abnormalities in the mucosa, submucosa and muscularis propria caused by inflammation, thickening of the entire esophageal wall and changes in the contractile properties of esophageal smooth muscles reflecting the effects of inflammation on the entire wall of the lower esophagus in reflux esophagitis regardless of whether it is erosive or endoscopically-negative. Treatment with lansoprazole resulted in normalization of esophageal wall struc...Continue Reading

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Citations

Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Masayuki SuzukiToshifumi Hibi
Oct 2, 2009·Journal of Clinical Biochemistry and Nutrition·Kazuhide HiguchiEiji Umegaki

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Methods Mentioned

BETA
transmission electron microscopy
biopsy

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