Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

Biomaterials Science
Po LiXiaonan Huang

Abstract

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4:Er3+,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as therapy agents by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency. This work highlights the potential of UCNP@NGO nanocomposites as an integrated theranostic nanoplatform for the UCL image combinatorial PTT of cancer, providing a promising candidate for clinical antitumor treatments.

References

Jan 15, 2004·Chemical Reviews·François Auzel
Aug 5, 2008·Biomaterials·Rufaihah Abdul Jalil, Yong Zhang
Nov 18, 2008·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·D Keith RoperM Hoepfner
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shiwei WuP James Schuck
Aug 14, 2010·Advanced Materials·Yanwu ZhuRodney S Ruoff
Apr 12, 2011·Journal of the American Chemical Society·Joshua T RobinsonHongjie Dai
Oct 1, 2011·Journal of the American Chemical Society·Qian LiuFuyou Li
Oct 20, 2011·Chemical Society Reviews·Jing ZhouFuyou Li
Jun 28, 2012·Journal of the American Chemical Society·Noah J J JohnsonFrank C J M van Veggel
Oct 13, 2012·Chemical Society Reviews·Kai YangZhuang Liu
Jan 15, 2014·Biomaterials·Li Ching OngYong Zhang
Mar 13, 2014·Chemical Reviews·Guanying ChenXiaoyuan Chen
Aug 16, 2014·Advanced Materials·Peng HuangXiaoyuan Chen
Apr 11, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Bhaskar GargYong-Chien Ling
Apr 22, 2015·Theranostics·Marco OrecchioniLucia Gemma Delogu
Nov 1, 2016·Nature Reviews. Nephrology·Nazila KamalyOmid C Farokhzad
Apr 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying-Hsia ShihMing-Jium Shieh
Nov 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bang-Ping JiangHong Liang

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Citations

Oct 18, 2018·Chemistry : a European Journal·Bang-Ping JiangXing-Can Shen
Feb 6, 2019·Biomaterials Science·André F GirãoPaula A A P Marques
Sep 12, 2019·Advanced Science·Minho KimJwa-Min Nam
Jul 3, 2021·Biomedicines·Manoj Kumar MahataKang Taek Lee
Jul 14, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Virginia MonteseguroVictor Lavín
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zahra Mohammadpour, Keivan Majidzadeh-A
Jan 7, 2022·Chemical Reviews·Bingzhu ZhengXiaogang Liu

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Methods Mentioned

BETA
fluorescence imaging
dynamic light scattering
infrared spectroscopy
fluorescence microscopy
transmission electron microscopy
flow cytometry

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