Lanthanum-containing bioparticles are associated with the influence of lanthanum on high phosphate mediated bone marrow stromal cells viability

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Jing BaiWerner E G Müller

Abstract

Lanthanum (La)-based binder appears effective in reducing serum inorganic phosphate (Pi) levels among chronic dialysis patients, yet concern remains about La accumulation in bone during long-term oral administration. In this study, the effect of lanthanum chloride (LaCl3) on bone marrow stromal cells (BMSCs) viability was investigated under high Pi situation. We found low concentration (10-9 M) of LaCl3 increased BMSCs viability, while high concentration (10-5 M) of LaCl3 not only inhibited BMSCs viability but also stimulated high Pi induced cell apoptosis. In addition, La-containing calcium phosphate (CaP) particles can be detected on cell surfaces and inside cells. We also found that inhibition of CaP formation by adding sodium pyrophosphate, a recognized inhibitor of hydroxyapatite formation, abrogated LaCl3 induced the BMSCs viability. For isolated La-containing CaP particles, the particle size increased and crystal phase switched with elevated concentration of LaCl3. These results demonstrated that La-containing CaP particles were associated with the process of LaCl3 mediated BMSCs viability and the physicochemical properties of these particles played an important role in modulating BMSCs function.

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Citations

Jan 29, 2019·Biomaterials Science·Xiao-Yuan PengZhen-Hong Zhu
May 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qiyang WangJunjie Guan
May 4, 2020·Biological Trace Element Research·Heming LiuKunzheng Wang
Jun 19, 2021·Nanotoxicology·Amir Mohammad MalvandiMahmoud Abudayyak

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Methods Mentioned

BETA
flow cytometry
FACS
transmission electron microscopy
protein assay
X-ray

Software Mentioned

Digital Micrograph
CellQuest Pro

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