Lanthanum induces extracellular signal-regulated kinase phosphorylation through different mechanisms in HeLa cells and NIH 3T3 cells

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Jian HuZhong Ming Qian

Abstract

Lanthanum ion (La3+) was generally regarded as calcium antagonist and was used as calcium channel blocker. However, its potential biological effects on cells were poorly understood. In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved. At a concentration of 30 microM or higher, La3+ enters the cells and activates ERK through a mechanism involving calmodulin activation inside the cells, which is similar to the action of intracellular Ca2+. However, at lower concentration, free La3+ promoted ERK phosphorylation in NIH 3T3 cells outside the cells through an unknown La3+ sensing mechanism, while Ca2+ exerted much weaker effect. The present results suggested that the biological effects of La3+ on cells maybe involve mechanisms beyond calcium antagonist.

References

Jan 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·F C Praeger, B A Gilchrest
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·H EnslenT R Soderling
Feb 24, 2001·Life Sciences·J Tang, J H Zhang
May 22, 2002·Cellular Signalling·Neus AgellPriam Villalonga
Dec 11, 2002·European Journal of Biochemistry·Xiu-Lian DuZhong-Ming Qian
Jan 22, 2003·In Vitro Cellular & Developmental Biology. Animal·Yucheng DaiZhu Wen
Mar 20, 2003·Molecular and Cellular Endocrinology·Susan A HobsonKarin D Rodland
Jun 6, 2003·Cell·Gali PragJames H Hurley
Nov 10, 2004·Journal of Cellular Biochemistry·Siwang YuZhong Ming Qian

❮ Previous
Next ❯

Citations

Apr 13, 2011·Biological Trace Element Research·William JenkinsJames Varani
Aug 18, 2010·Investigative Radiology·Narasimharao BhagavathulaJames Varani
Mar 30, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fei GuoYang Wang
Oct 16, 2007·Journal of Inorganic Biochemistry·Qin YangKui Wang
Jul 10, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xin PanSiwang Yu
May 23, 2018·International Journal of Molecular Sciences·Kjell De VrieseSteffen Vanneste

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.