LAP (LC3-associated phagocytosis): phagocytosis or autophagy?

Médecine sciences : M/S
Mathilde GalaisMartine Biard-Piechaczyk

Abstract

Phagocytosis and macroautophagy, named here autophagy, are two essential mechanisms of lysosomal degradation of diverse cargos into membrane structures. Both mechanisms are involved in immune regulation and cell survival. However, phagocytosis triggers degradation of extracellular material whereas autophagy engulfs only cytoplasmic elements. Furthermore, activation and maturation of these two processes are different. LAP (LC3-associated phagocytosis) is a form of phagocytosis that uses components of the autophagy pathway. It can eliminate (i) pathogens, (ii) immune complexes, (iii) threatening neighbouring cells, dead or alive, and (iv) cell debris, such as POS (photoreceptor outer segment) and the midbody released at the end of mitosis. Cells have thus optimized their means of elimination of dangerous components by sharing some fundamental elements coming from the two main lysosomal degradation pathways.

References

Mar 13, 2008·Médecine sciences : M/S·Arnaud A MailleuxJoan S Brugge
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jennifer MartinezDouglas R Green
May 23, 2012·Trends in Cell Biology·Oliver Florey, Michael Overholtzer
Jun 20, 2012·Infection and Immunity·André Moraes NicolaArturo Casadevall
Jul 23, 2013·Cell·Ji-Young KimThomas A Ferguson
Jan 5, 2014·Nature Reviews. Microbiology·Ju Huang, John H Brumell
Jan 15, 2014·Autophagy·Susana Romao, Christian Münz
Mar 19, 2016·Cell Death and Differentiation·Douglas R GreenJ Martinez
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rachasak BoonhokMarisa Ponpuak
Jun 10, 2016·PLoS Pathogens·Christine MatteAlbert Descoteaux
Dec 16, 2016·Cell Host & Microbe·Tonia Akoumianaki, Georgios Chamilos
Apr 4, 2017·Médecine sciences : M/S·Beatriz Villarejo-Zori, Patricia Boya
Apr 4, 2017·Médecine sciences : M/S·Isabelle VergneMartine Biard-Piechaczyk
Apr 4, 2017·Médecine sciences : M/S·Sylviane Muller
Apr 11, 2017·Cellular & Molecular Immunology·Yushun WanYing Zhu
Jul 30, 2017·Biology of the Cell·Gholamreza Fazeli, Ann M Wehman
Aug 30, 2017·Journal of Molecular Biology·Bradlee L HeckmannDouglas R Green
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Stefan KösterJennifer A Philips
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gabriel MitchellDaniel A Portnoy
Mar 16, 2018·Cell Host & Microbe·Alexander GluschkoMichael Schramm
Aug 22, 2018·Nature Communications·Angeliki M AndrianakiGeorgios Chamilos
Feb 23, 2019·Journal of Cell Science·Bradlee L Heckmann, Douglas R Green

Citations

Mar 12, 2020·Journal of Cancer Research and Clinical Oncology·Yu-Chen MengYan-Qiang Hou
Oct 31, 2020·Frontiers in Immunology·Baptiste PradelLucile Espert

Related Concepts

Immune complex
Autophagy
Cell Survival
Cytoplasm
Mitosis
Necrotic Debris
Phagocytosis
GNAT1 protein, human
Anatomical Segmentation
Extracellular

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