Laparoscopic cytoreductive nephrectomy: a three-center retrospective analysis

Journal of Endourology
Christopher BlickMark Sullivan

Abstract

Metastatic renal cell carcinoma is associated with a poor prognosis. Given the current lack of effective systemic therapies and data suggesting a survival benefit from cytoreductive nephrectomy (CRN) before systemic therapy, we have retrospectively analyzed the experience of laparoscopic cytoreductive nephrectomy (LCRN) in three U.K. centers. The focus of this study was to assess the peri- and postoperative safety and hence feasibility of LCRN in the United Kingdom. Twenty-five patients with metastatic renal cell carcinoma deemed suitable for systemic therapy underwent LCRN in three U.K. centers over a 4-year period. The tumors ranged from 3.4 cm in diameter to 12 cm. Operating times ranged from 89 (minimum) to 310 minutes (maximum), median 175 minutes. The median amount of blood loss was 150 mL, and hence the transfusion rate was low with only one patient requiring on-table transfusion and two patients requiring additional blood before discharge. Hospital stay ranged between 2.5 and 11 days; median postoperative stay was 3 days. In our initial experience, LCRN seems safe and feasible with low morbidity and a good perioperative outcome.

References

Mar 1, 1977·The Journal of Urology·J E MontieD K Montague
Oct 1, 1977·The Journal of Urology·S Z FreedM Gordon
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Aug 1, 1993·The Journal of Urology·S G MarcusM M Walther
May 11, 1999·JAMA : the Journal of the American Medical Association·W H ChowJ F Fraumeni
Dec 1, 2000·The Urologic Clinics of North America·I S Gill
Dec 31, 2002·Expert Review of Anticancer Therapy·Gerald H Mickisch
Jan 23, 2003·Current Urology Reports·Robert C Flanigan
Aug 28, 2003·Current Treatment Options in Oncology·Steven C CampbellJoseph I Clark
Aug 28, 2003·Current Treatment Options in Oncology·Surena F Matin
Feb 10, 2004·The Journal of Urology·Robert C FlaniganE David Crawford
Aug 5, 2004·BJU International·Antonio FinelliInderbir S Gill
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 26, 2005·World Journal of Urology·Gerald H Mickisch, Roland H Mattes
Apr 7, 2005·World Journal of Urology·John S LamRobert A Figlin
Jul 25, 2006·Journal of Endourology·Manuel S EisenbergChristopher J Kane
Feb 14, 2007·The Journal of Urology·A Karim KaderChristopher G Wood
Nov 11, 2008·The Urologic Clinics of North America·Paul Russo, Matthew Francis O'Brien
Jul 27, 2010·Journal of Endourology·Christopher BlickMark Sullivan

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Citations

Sep 19, 2012·Journal of Endourology·James S RosoffJoseph J Del Pizzo
Apr 17, 2016·World Journal of Urology·Luciano Nunez BragayracThomas Schwaab
Jul 27, 2010·Journal of Endourology·Christopher BlickMark Sullivan
Nov 1, 2018·Die Naturwissenschaften·Tomer J CzaczkesCristina Tuni

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