Laparoscopic electrocautery of the ovaries versus recombinant FSH in clomiphene citrate-resistant polycystic ovary syndrome. Impact on women's health-related quality of life

Human Reproduction
Madelon van WelyFulco van der Veen

Abstract

Ovulation induction with gonadotrophins is the standard treatment strategy for women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). Laparoscopic electrocautery of the ovaries is an alternative treatment modality, leading to a comparable cumulative pregnancy rate. In deciding which treatment to opt for, women's health-related quality of life (HRQoL) should be taken into account. A total of 168 CC-resistant women with PCOS were randomly assigned to receive either the electrocautery strategy, entailing laparoscopic electrocautery of the ovaries followed by CC and recombinant FSH (rFSH) if anovulation persisted, or ovulation induction with rFSH. We assessed women's HRQoL with the standard questionnaires Short Form-36, Rotterdam Symptom Checklist and Center for Epidemiological Studies Depression Scale, administered before randomization and 2, 12 and 24 weeks thereafter. The intention to treat analysis revealed no significant differences between the treatment groups on any of the scales at any point during follow-up. In women without an ongoing pregnancy, those treated with rFSH showed significantly more depressive symptoms than women allocated to the electrocautery strategy, with or without CC, although dif...Continue Reading

Associated Clinical Trials

References

Jul 18, 1992·BMJ : British Medical Journal·J E BrazierL Westlake
Jun 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A H Zwinderman
Feb 1, 1987·American Journal of Obstetrics and Gynecology·E Greenblatt, R F Casper
Aug 1, 1994·American Journal of Public Health·T P SuurmeijerW J van den Heuvel
Apr 1, 1996·Baillière's Clinical Endocrinology and Metabolism·B W Donesky, E Y Adashi
May 5, 2000·The Cochrane Database of Systematic Reviews·C FarquharR Lilford
Nov 1, 2001·The Cochrane Database of Systematic Reviews·C FarquharR Lilford
Aug 31, 2002·Human Reproduction·Adam Balen, Kathy Michelmore
Jul 23, 2003·Human Reproduction·S Christin-MaitreUNKNOWN Recombinant FSH Study Group

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Citations

Mar 1, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Wessam M AbuelgharMarian S Khalil
May 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group
Oct 18, 2008·Human Fertility : Journal of the British Fertility Society·G L JonesW L Ledger
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Adam Balen
Jun 15, 2012·The Cochrane Database of Systematic Reviews·Cindy FarquharJane Marjoribanks
Jun 7, 2019·Archives of Gynecology and Obstetrics·Pinar AnginKemal Atasayan
Feb 13, 2020·The Cochrane Database of Systematic Reviews·Esmée M BordewijkMadelon van Wely

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