Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients

Endoscopy
S FujiokaT Tsuji

Abstract

Antimitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) has been difficult to diagnose. Laparoscopic features of AMA-negative PBC were evaluated in comparison with those of AMA-positive PBC and autoimmune hepatitis. 71 patients who fulfilled the diagnostic criteria for PBC were enrolled in the study; 48 were AMA-positive and 23 were AMA-negative. As a disease control, 46 autoimmune hepatitis patients were included. Both the frequency and specificity of each laparoscopic finding were evaluated. A laparoscopic scoring system was introduced, which used, common and uncommon laparoscopic findings, and was evaluated for the diagnosis of AMA-negative PBC. The characteristic laparoscopic findings for AMA-positive PBC were yellowish-white marking (92 %), dark-brown discoloration (73 %), gentle undulation (67 %), reddish patch (38 %), and yellowish-white nodules (32 %). On the other hand, laparoscopic findings such as trench-like depression, reddish markings, and wide and small depressions were uncommon in PBC compared with autoimmune hepatitis. The frequencies of characteristic and uncommon laparoscopic findings did not differ statistically between AMA-positive and AMA-negative PBC, but were different between AMA-posit...Continue Reading

Citations

Jul 23, 2013·Molecular BioSystems·Elena NikonovaBoris N Kholodenko
Jan 20, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Naoki TanakaKendo Kiyosawa
Mar 1, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Suguru OguraHiromitsu Kumada
Sep 13, 2003·World Journal of Gastroenterology : WJG·Xiao-Hua JiangXian-Tao Kong

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