PMID: 11926567Apr 3, 2002Paper

Laparoscopic fundoplication versus lansoprazole for gastro-oesophageal reflux disease. A pH-metric comparison

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Marzio FrazzoniE De Micheli

Abstract

Treatment strategies that abolish abnormal reflux could prevent long-term complications of gastro-oesophageal reflux disease. To compare the efficacy of laparoscopic fundoplication and lansoprazole in abolishing abnormal reflux in patients with gastro-oesophageal reflux disease. Study population comprised 130 patients referred for possible antireflux surgery and with heartburn as the dominant symptom. After oesophageal manometric and pH-metric evaluation and detailed information 55 patients asked to undergo laparoscopic antireflux surgery while 75 chose a medical treatment regimen based on lansoprazole. Treatment efficacy was assessed by ambulatory oesophageal pH-monitoring. All 55 patients who underwent fundoplication became free of heartburn: oesophageal pH-monitoring gave normal results in 85%. In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients). Lansoprazole at individualized dosages was significantly more effective than laparoscopic fundoplication, in the short-term, in abolishing abnormal reflux in gastro-oesophageal reflux disease patients.

References

Mar 19, 1992·The New England Journal of Medicine·J E Richter
Oct 26, 1995·The New England Journal of Medicine·S VigneriA Pilotto
Aug 1, 1994·Annals of Internal Medicine·E C Klinkenberg-KnolS G Meuwissen
Apr 1, 1996·Gut·D C GotleyL Nathanson
Aug 1, 1997·Scandinavian Journal of Gastroenterology·M ViljakkaJ Isolauri
Dec 31, 1997·American Journal of Surgery·D W RitterM Westmoreland
Dec 29, 1998·Annals of Internal Medicine·J K DiBaiseE M Quigley
Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Mar 18, 1999·The New England Journal of Medicine·S Cohen, H P Parkman
Jun 22, 2000·The New England Journal of Medicine·J ConcatoR I Horwitz
Sep 7, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S PassarettiF Baldi
Oct 13, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G N Tytgat, J W van Sandick

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Citations

Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R A Hinder
Sep 13, 2012·World Journal of Gastroenterology : WJG·Edoardo SavarinoVincenzo Savarino
Apr 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marzio FrazzoniGianluigi Melotti
Oct 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M FrazzoniG Melotti
May 5, 2011·Alimentary Pharmacology & Therapeutics·M FrazzoniG Melotti
Dec 18, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N de BortoliS Marchi
Jan 31, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M FrazzoniG Melotti
Jul 21, 2012·Journal of Economic Entomology·Sebastain N AwondoMark Abney
Jul 10, 2009·Biology Letters·Marina Elliott, Mark Collard
Sep 25, 2008·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·T S Kornmo, T E Ruud

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