Laparoscopic liver resection for large HCC: short- and long-term outcomes in relation to tumor size

Surgical Endoscopy
Giovanni Battista Levi SandriGiuseppe Maria Ettorre

Abstract

In this study, we aim to assess the impact of tumor size on clinical and oncological outcomes in patients undergoing laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC). LLR has been shown to be feasible, safe, and oncologically efficient. However, it has been slow to develop in patients with HCC who often suffer from chronic liver disease which represents an additional challenge for the surgeon. The experience with large HCCs is even more limited. Between 2003 and 2016, 172 patients from two high-volume liver surgery centers underwent LLR for HCC. Prospectively collected data were analyzed after stratification in 3 groups according to tumor major diameter (group 1: < 3 cm; group 2: between 3 and 5 cm; group 3: ≥ 5 cm). Perioperative and long-term outcomes were compared between the three groups and sub-analyses were carried out on the extent and location of the resections. Groups 1, 2, and 3 consisted of 82, 52, and 38 patients, respectively. Minor and major resections were performed in 98.8% and 1.2% in group 1, in 90.4% and 9.6% in group 2, and in 68.4% and 31.6% in group 3, respectively. Postero-superior "technically major" resections were performed in 15.8% patients in group 1, in 19.2% in group 2, and in ...Continue Reading

References

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Citations

Apr 5, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giovanni B Levi SandriCristiano Guidetti
Nov 26, 2020·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Prasad WagleParesh Varty
Feb 21, 2021·Journal of Hepato-biliary-pancreatic Sciences·Taku AokiUNKNOWN Endoscopic Liver Surgery Study Group of Japan
Jun 3, 2021·JAMA Surgery·Burak GörgecMohammed Abu Hilal
Aug 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Tousif KabirBrian K P Goh
Oct 8, 2021·Cancer Biotherapy & Radiopharmaceuticals·Wang-Yang YeYi-Wu Dang

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