Laparoscopic pelvic lymphadenectomy in a patient with cervical cancer stage Ib1 complicated by a twin pregnancy

Journal of Minimally Invasive Gynecology
Giovanni FaveroChristhardt Köhler

Abstract

Cervical cancer is the most frequently observed malignancy during pregnancy. The presence of nodal metastasis is the most important negative predictor factor, and its assessment is crucial in deciding whether the pregnancy can safely continue. To our knowledge, this is the first report of a twin pregnancy complicated by cancer of the uterine cervix that was successfully treated with laparoscopic pelvic lymphadenectomy and subsequently with neoadjuvant chemotherapy. A 35-year-old woman, gravida 2, para 1, with a dichorionic-diamniotic twin pregnancy underwent laparoscopic staging of the pelvic lymph nodes at 17 weeks of gestation. Cervical adenocarcinoma, grade 2, stage 1b1 with lymphovascular space invasion was diagnosed. Nineteen negative nodes were removed, and the patient was counseled to continue the pregnancy. On the basis of tumor size and detection of lymphovascular space invasion, cisplatin as neoadjuvant chemotherapy was administered until week 32 of gestation, when a cesarean section delivery was performed, along with radical hysterectomy. No complications to the neonates or to the mother due to the therapy were observed. This case demonstrates the safety of operative nodal staging during gestation, even in a twin pre...Continue Reading

References

Jul 31, 2001·Human Reproduction Update·B WeiszM Lishner
Jan 19, 2008·Gynecologic Oncology·Souhail AlouiniPatrice Mathevet

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Citations

Oct 22, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rehana DawoodSean Kehoe
Jul 29, 2011·Obstetrical & Gynecological Survey·Emily M Ko, Linda Van Le
Jan 25, 2013·Obstetrics and Gynecology·Flora ZagouriRupert Bartsch
Nov 6, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Arunachalam Ilancheran
Dec 29, 2013·Gynecologic Oncology Case Reports·Christine Rojas, John W Moroney
Dec 29, 2013·Gynecologic Oncology Case Reports·D F KolomainenJ H Shepherd
Oct 25, 2016·Journal of Minimally Invasive Gynecology·Christhardt KöhlerGiovanni Favero
Oct 2, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yoshikazu NagaseTadashi Kimura
Apr 15, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mariana CorintiRenato Moretti-Marques

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