Laparoscopic Radical Prostatectomy in Patients with High-Risk Prostate Cancer: Feasibility and Safety. Results of a Multicentric Study

Journal of Endourology
Virginia VarcaFranco Gaboardi

Abstract

In Western countries about 25% of prostate cancer (PCa) are high-risk tumors at presentation and its treatment is still a matter of debate among urologists. When a surgical approach is preferred the use of a mininvasive tecnique is still difficult due to the lack of data supporting it in literature. The aim of this study is to evaluate feasibility and safety of laparoscopic radical prostatectomy (LRP) for high-risk PCa. The study included 1114 patients with high-risk PCa submitted to LRP between 1998 and 2014. High-risk patients were defined according to D'Amico classification. We collected functional and oncological long-term outcomes and evaluated with univariate and multivariate analyses the role of predictive factors for survival and biochemical recurrence (BR). Mean age at treatment was 62 ± 8 years; mean follow-up was 74 ± 50 months. We obtained an overall survival (OS) of 96.6% at a mean follow-up of 74 months (1076 patients) and a disease-free survival of 66.2% (737 patients). Age (p = 0.0006), pT (p < 0.0001), pN (p = 0.0018), and surgical margins (p = 0.0076) resulted as independent predictors for BR in multivariate analysis. pN (p = 0.0025) and Gs (p = 0.0003) are independent predictors for OS and cancer-specific sur...Continue Reading

References

Apr 11, 2003·The Journal of Urology·Jens RassweilerThomas Frede
Feb 10, 2004·The Journal of Urology·Ulrike ZwergelMichael Stoeckle
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
Oct 9, 2007·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
May 8, 2014·BJU International·Antonina Di BenedettoChristopher G Eden
Aug 8, 2014·BJU International·Ricardo SoaresChristopher G Eden

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Citations

Oct 29, 2020·World Journal of Surgical Oncology·Ben XuQian Zhang

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

SAS

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