Laparoscopic retroperitoneal lymph node dissection: does it still have a role in the management of clinical stage I nonseminomatous testis cancer? A European perspective

European Urology
J J RassweilerGünter Janetschek

Abstract

Laparoscopic retroperitoneal lymph node dissection (L-RPLND) is not recommended as standard tool in European Association of Urology (EAU) guidelines. To update the role of L-RPLND in patients with clinical stage I nonseminomatous germ cell tumour (NSGCT) compared to open retroperitoneal lymph node dissection (O-RPLND). A systematic literature search from 1992 to 2008 was performed in Medline, EMBASE, and Cochrane. The largest series from each group was considered. Comparative analysis was based on raw data of series published in 2000 and later. Results of >800 patients treated by L-RPLND reported in 34 articles were analyzed. Lymph node dissection (LND) was based on modified templates, removing an average of 16 (5-36) lymph nodes. At experienced centres, complication rates were 15.6% (9.4-25.7), including 2% (0-5) retrograde ejaculation and 1.7% (0-6) reintervention. Operating room times are longer compared to O-RPLND (204 vs 186min). Five publications with a follow-up of 63 (36-89) mo include 557 patients. One hundred twenty-six of 140 (90%) patients with positive nodes (25%, range: 17-38) received adjuvant chemotherapy, resulting in a local relapse rate of 1.4% (0.7-2.3) with no in-field recurrence; rate of distant relapses w...Continue Reading

References

Sep 5, 1998·The Urologic Clinics of North America·J P Donohue, R S Foster
Mar 22, 2002·Journal of the American Academy of Dermatology·Thomas J Connelly
Mar 23, 2004·World Journal of Urology·Stefan CorvinArnulf Stenzl
Dec 22, 2004·International Braz J Urol : Official Journal of the Brazilian Society of Urology·M Tobias-MachadoEric R Wroclawski
Mar 23, 2005·Urology·Mohamad E AllafLouis R Kavoussi
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonJoel Sheinfeld
Jan 18, 2006·Urology·Patrick DavolDaniel Rukstalis
May 3, 2006·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Frederico R RomeroLouis R Kavoussi
Sep 26, 2006·European Urology·Peter Albers
Mar 17, 2007·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Endre HolmanMorshed A Salah
Jun 15, 2007·The Journal of Urology·Stephen D W BeckRichard S Foster

❮ Previous
Next ❯

Citations

Apr 25, 2012·Der Urologe. Ausg. A·L Lusuardi, G Janetschek
Apr 27, 2012·Der Urologe. Ausg. A·P Albers
Nov 20, 2013·Der Urologe. Ausg. A·S Krege
Jul 19, 2013·Surgical Endoscopy·Lucia Chung, Patrick J O'Dwyer
Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X DurandUNKNOWN Oncology Committee of the French Association of Urology (CCAFU)
Jul 16, 2010·Journal of Endourology·Alon Z Weizer, Jeffrey S Montgomery
Sep 23, 2011·Journal of Endourology·Michael W GardnerRobert S Figenshau
Aug 2, 2012·Therapeutic Advances in Urology·Axel Heidenreich, David Pfister
Mar 29, 2014·Urology Annals·Cesar E ErcoleJihad H Kaouk
Apr 5, 2014·Der Urologe. Ausg. A·F ZengerlingM Schrader
Mar 13, 2016·Current Urology Reports·Heather J ChalfinMohamad E Allaf
Oct 21, 2009·BJU International·Christian WinterPeter Albers
Jul 29, 2010·Cancer·R Houston ThompsonJoel Sheinfeld
Oct 15, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Maria Carmen MirJihad H Kaouk
Jul 29, 2015·The Urologic Clinics of North America·Thomas Kunit, Günter Janetschek
Aug 10, 2016·Journal of Robotic Surgery·Girdhar S BoraArup K Mandal
Nov 1, 2016·Nature Reviews. Urology·Michal ChovanecCostantine Albany
Feb 24, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Aggelos TselosAlexandros Papalampros
Sep 13, 2017·Nature Reviews. Urology·Wesley W LudwigMohamad E Allaf
Feb 22, 2012·Urologia·Roberto SalvioniFlavio Crippa
May 18, 2018·Oncology Research and Treatment·Axel HeidenreichDavid Pfister
Jul 7, 2018·Current Opinion in Urology·Ryan P WerntzScott E Eggener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.