Laparoscopic thermal ablation of hepatic neuroendocrine tumor metastases

Surgery
Allan E SipersteinA Gitomirsky

Abstract

Neuroendocrine tumor metastases to the liver are generally slow growing, but patients suffer from hormone hypersecretion despite aggressive multimodality therapy. A minimally invasive method of tumor ablation affords symptomatic improvement with minimal morbidity. Radiofrequency electrical energy is delivered to tissues via a 4-prong catheter resulting in tissue heating to 60 to 70 degrees C and cell death. Porcine studies were conducted to define appropriate parameters for energy delivery and then applied to patients using laparoscopic techniques. In the porcine model 3.5 to 4 cm lesions were reproducibly created in 15 minutes using 30 to 50 W of power. The ablation process was monitored via temperature feedback from thermocouples in the catheter tips and by a hyperechoic blush noted on ultrasonography. Laparoscopic thermal ablation of 13 tumors in six patients with carcinoid (two patients), gastrinoma, insulinoma, nonsecreting islet cell cancer, or medullary thyroid cancer was performed. There were no intraoperative complications, and all patients were discharged the next day. Successful ablation was confirmed by spiral-computed tomography and by symptomatic improvement in patients with secreting tumors. Laparoscopic thermal ...Continue Reading

References

May 1, 1992·Journal of Vascular and Interventional Radiology : JVIR·J P McGahanP D Browning
May 1, 1989·World Journal of Surgery·B G PerssonS Bengmark
Jan 1, 1995·Gastrointestinal Endoscopy·L BuscariniE Buscarini
Jan 1, 1995·World Journal of Surgery·I IhseS Tibblin
Feb 1, 1996·World Journal of Surgery·G Akerström
Sep 1, 1996·AJR. American Journal of Roentgenology·S RossiL Buscarini

❮ Previous
Next ❯

Citations

Jun 22, 2000·Journal of Surgical Oncology·A BeneventoR Dionigi
Mar 19, 2005·Abdominal Imaging·Y NiG Marchal
Mar 9, 2005·European Radiology·Elisabetta BuscariniAlessandro Zambelli
Apr 11, 2006·Langenbeck's Archives of Surgery·Philipp HildebrandHans-Peter Bruch
Jun 12, 2002·Current Treatment Options in Oncology·M L Li, J A Norton
Jul 31, 2013·Current Treatment Options in Oncology·Jonathan Strosberg
Jan 22, 2004·Current Urology Reports·Jonathan J Hwang, McClellan M Walther
Jan 22, 2004·Current Urology Reports·Brian R MatlagaM Craig Hall
Sep 4, 2004·Current Treatment Options in Gastroenterology·James M. McLoughlinJeffrey T. Lamont
Jun 12, 1999·American Journal of Surgery·C H ScudamoreD A Owen
Jul 4, 1998·European Journal of Radiology·L Solbiati
Feb 17, 2000·Surgical Oncology·S S Yoon, K K Tanabe
Dec 24, 2002·Journal of the American College of Surgeons·Scott R SchellEdward M Copeland
Mar 3, 1998·Journal of the American College of Surgeons·J A van Heerden
Jun 8, 2006·Nature Clinical Practice. Oncology·Kelvin HongJean-Francois H Geschwind
Apr 23, 2002·Clinical Endocrinology·Adrian ScottRichard Donnelly
Oct 31, 2002·Surgery·Boris W Kuvshinoff, David M Ota
Apr 1, 2010·Physics in Medicine and Biology·Jingfeng JiangTimothy J Hall
Jan 27, 2010·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Ibrahim A SalamaAhmed El-Refaie
Sep 26, 2008·Thyroid : Official Journal of the American Thyroid Association·Marieke W J L A E WertenbroekKoert P de Jong
Apr 18, 2000·Annals of Surgery·W C ChapmanJ W Christman
Apr 25, 2001·Journal of Clinical Gastroenterology·H HorigomeM Itoh
Nov 18, 2000·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·O GolettiE Cavina
May 13, 2005·Gut·J K RamageUNKNOWN UKNETwork for Neuroendocrine Tumours
Nov 5, 2011·Gut·John K RamageUNKNOWN UK and Ireland Neuroendocrine Tumour Society
Apr 21, 2012·International Journal of Hepatology·Ron BasuroyJohn K Ramage
Feb 22, 2007·Neuroendocrinology·Massimo FalconiUNKNOWN European Neuroendocrine Tumor Society
Jun 28, 2006·World Journal of Surgical Oncology·Liesbeth M VeenendaalRichard van Hillegersberg
Nov 2, 2007·Annals of Surgical Innovation and Research·Philipp HildebrandHans-Peter Bruch
May 8, 2003·Annals of Surgical Oncology·Steven A Curley
Jan 3, 2001·AJR. American Journal of Roentgenology·J P McGhana, G D Dodd
Oct 20, 2001·AJR. American Journal of Roentgenology·T de Baere

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Islet Cell

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arises in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Carcinoma here.

Carcinoma, Islet Cell (Keystone)

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arise in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on islet cell carcinoma in this feed.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.