Large animal model of acute right ventricular failure with functional tricuspid regurgitation

International Journal of Cardiology
Marcin MalinowskiTomasz A Timek

Abstract

Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. Ten adult sheep had pressure sensors placed in the LV, RV, and right atrium while sonomicrometry crystals were implanted around tricuspid annulus and on the RV. Animals were studied open-chest to assess for RV function and FTR after: (1) volume infusion, (2) pulmonary artery constriction, (3) 5 min posterior descending artery occlusion, and (4) combination of all interventions. Hemodynamic, echocardiographic, and sonomicrometry data were collected at baseline and after every intervention. RV dimensions, RV strain, and annular area, perimeter, and size were calculated from crystal coordinates. The model was validated in six additional sheep studied only before and after combined interventions. Neither volume infusion, pulmonary hypertension, nor ischemia were associated with RVF or clinically significant TR when applied separately but combined resulted in RVF and greater than moderate FTR. In the validation group, maximal RV volume ...Continue Reading

Citations

Dec 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Pierre SicardSylvain Richard
Jul 3, 2020·Animal Models and Experimental Medicine·Michael Nguyen-TruongZhijie Wang
Jan 24, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Qian YanEdgar Lik Wui Tay
Jan 27, 2019·The Journal of Thoracic and Cardiovascular Surgery·Tomasz JazwiecTomasz A Timek

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