Large Animal Models of an In Vivo Bioreactor for Engineering Vascularized Bone

Tissue Engineering. Part B, Reviews
Banu AkarEric M Brey

Abstract

Reconstruction of large skeletal defects is challenging due to the requirement for large volumes of donor tissue and the often complex surgical procedures. Tissue engineering has the potential to serve as a new source of tissue for bone reconstruction, but current techniques are often limited in regards to the size and complexity of tissue that can be formed. Building tissue using an in vivo bioreactor approach may enable the production of appropriate amounts of specialized tissue, while reducing issues of donor site morbidity and infection. Large animals are required to screen and optimize new strategies for growing clinically appropriate volumes of tissues in vivo. In this article, we review both ovine and porcine models that serve as models of the technique proposed for clinical engineering of bone tissue in vivo. Recent findings are discussed with these systems, as well as description of next steps required for using these models, to develop clinically applicable tissue engineering applications.

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Citations

Mar 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexander M TataraAntonios G Mikos
Aug 8, 2021·Cells·Filip Simunovic, Günter Finkenzeller

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Methods Mentioned

BETA
biopsies
X-ray

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