Large artery stiffness: structural and genetic aspects

Clinical and Experimental Pharmacology & Physiology
B A KingwellG L Jennings

Abstract

1. Large artery stiffness is a principal determinant of pulse pressure and both are related to cardiovascular mortality independently of other major risk factors. A clearer understanding of the structural and genetic processes that contribute to large artery properties may provide novel approaches to therapy. 2. Age, atherosclerosis and gender are three important factors that contribute to large artery stiffening. Each influences the artery elastic matrix and its relationship to medial smooth muscle cells. Genetic and hormonal modulation of the extracellular matrix proteins and their regulators, including matrix metalloproteinases (MMPs), may account for some interindividual differences. 3. In a study of 213 healthy individuals and 105 patients with coronary artery disease (CAD), we examined whether stromelysin-1 (MMP-3) genotype, determined by the 5A/6A promoter polymorphism, influences large artery stiffening. In healthy individuals, the 5A/5A genotype was linked with stiffer large arteries and higher systolic blood pressure compared with other genotypes. 4. Genetic variation in the extracellular matrix protein fibrillin-1, using a pentanucleotide repeat polymorphism, was assessed as a potential determinant of large artery st...Continue Reading

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Citations

Nov 23, 2005·Journal of Clinical Laboratory Analysis·Tamara DjurićDragan Alavantić
Jun 7, 2006·Postgraduate Medical Journal·B Jani, C Rajkumar
Sep 18, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tsung-Hsien LinSheng-Hsiung Sheu
Feb 10, 2006·Journal of Hypertension·Alexandre Persu
Nov 4, 2005·European Heart Journal·Katerina K NakaAndrew H Henderson
Sep 4, 2015·Physiological Measurement·L BocchiM Bevilacqua
May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·L LawrensonR S Richardson
Dec 16, 2005·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Maria-Benedicta EdwardsIan R Young
Feb 19, 2005·Journal of Applied Physiology·Allison E DeVanHirofumi Tanaka
Nov 12, 2020·Integrated Blood Pressure Control·Valeria BisogniGaetano Vaudo

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