Large B-cell lymphoma of the uterine corpus: case report with immunohistochemical and molecular study

Gynecologic Oncology
A AlvarezF Sacristán

Abstract

Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage tissue. Immunohistochemical study showed tumoral cells of B-cell nature. Two different polymerase chain reaction (PCR) techniques showed immunoglobulin heavy chain gene rearrangement and we could not demonstrate, with PCR technique, either Epstein-Barr virus or papilloma virus infection. Total hysterectomy with bilateral salpingo-oophorectomy was carried out and adjuvant chemotherapy was given. She was alive and free of disease after a follow-up period of 7 years, and the patient has been in perfect health.

References

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Citations

Dec 3, 2005·Leukemia & Lymphoma·C KellerB Alobeid
Jul 3, 2013·Critical Reviews in Oncology/hematology·Chiara Di TucciPierluigi Benedetti Panici
Apr 26, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·F LeungD Riethmuller
Jul 11, 2001·Advances in Anatomic Pathology·R VangM Deavers
Sep 22, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jon RittenbachJun Wang
Dec 1, 2004·Histopathology·G J Thomas, A Dogan

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