Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution.

Blood
Saad Sirop KenderianGrzegorz S Nowakowski

Abstract

A number of reports have shown a propensity of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) to transform into diffuse large B-cell lymphoma (DLBCL). Long-term data on the incidence and outcomes of transformed NLPHL are lacking. A comprehensive analysis of the actively maintained Mayo Clinic Lymphoma Database was performed. Between 1970 and 2011, 222 consecutive adult patients with new untreated NLPHL were identified. Median age at diagnosis was 40 years, and 146 (66%) were males. The median follow-up was 16 years. Seventeen patients (7.6%) developed a transformation to DLBCL. The median time to transformation was 35 months (range, 6-268 months). Based on the observed 17 transformations during 2304 patient-years of follow-up, the rate of transformation was 0.74 per 100 patient-years. In a multivariate analysis, use of any prior chemotherapy ( ITALIC! P= .04) and splenic involvement ( ITALIC! P= .03) were significantly associated with increased risk of transformation. The 5-year overall survival (OS) in those with transformed disease was 76.4%, and transformation did not adversely affect OS when compared with patients who did not experience transformation. In this large single-institution cohort with long-term follow-u...Continue Reading

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Citations

Jul 15, 2017·Hematological Oncology·Aliihsan GemiciUNKNOWN ThREG, Turkish hematology Research and Education Group
Feb 10, 2019·Journal of Clinical Medicine·Susanne HofmannMichael Schmitt
Feb 17, 2019·Blood·Sven BorchmannDavid J Straus
Apr 23, 2016·Blood·Michelle Fanale
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Aug 10, 2020·Indian Journal of Pathology & Microbiology·Sonali Susmita NayakSumeet Gujral
Jan 11, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L Bartlett
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Oct 13, 2020·The Journal of Pathology·Sibrandes Poppema
Dec 3, 2020·Frontiers of Medicine·Bin GuDepei Wu

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