Large-bite bis(phosphite) ligand containing mesocyclic thioether moieties: synthesis, reactivity, group 11 (Cu(I), Au(I)) metal complexes and anticancer activity studies on a human cervical cancer (HeLa) cell line

Dalton Transactions : an International Journal of Inorganic Chemistry
D SureshJoel T Mague

Abstract

The large-bite bis(phosphite) ligand [{(-OC(10)H(6)(mu-S)C(10)H(6)O-)P{mu-(-OC(10)H(6)(mu-S)C(10)H(6)O-)}P(-OC(10)H(6)(mu-S)C(10)H(6)O-)}] (Pinsertion markP) () was obtained by the reaction of PCl(3) and thiobis(2,2'-naphthol) (). The stoichiometric reactions of with elemental sulfur and selenium afforded the corresponding chalcogenide derivatives [(E)Pinsertion markP(E)] (, E = S; , E = Se) in good yield. Treatment of two equivalents of [ClAu(SMe(2))] with afforded a dinuclear complex [ClAu(Pinsertion markP)AuCl] (), whereas the 1 : 1 reaction with CuI yielded the [(Pinsertion markP)CuI] () complex. The copper(i) complex on treatment with various pyridyl derivatives, produced mixed-ligand complexes [(Pinsertion markP)CuI(NC(5)H(5))] (), [(Pinsertion markP)Cu(2,2'-bpy)]I (), [(Pinsertion markP)Cu(1,10-phen)]I () and {[(Pinsertion markP)Cu(4,4'-bpy)]I}(infinity) (). The compounds were tested for their cytotoxic activity on the human cervical cancer (HeLa) cell line. Compounds and were found to inhibit proliferation of HeLa cells significantly. These agents also induced apoptotic cell death in cancer cells. Evidence presented in this study indicated that the compounds and activate the tumor suppressor protein p53 in the colon ade...Continue Reading

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Citations

Jun 13, 2015·Journal of Medicinal Chemistry·Penumaka NagababuBojja Sreedhar
Nov 30, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Massimo RigoChristian Müller
Dec 19, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Jing XiangChi-Chiu Ko
Oct 27, 2011·Metallomics : Integrated Biometal Science·Arnaud Gautier, Federico Cisnetti
Jul 18, 2019·Physical Chemistry Chemical Physics : PCCP·Adrien SchlachterPierre D Harvey
Oct 1, 2008·Biochemical Pharmacology·Krishnan Rathinasamy, Dulal Panda

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