Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.

Pharmacology & Therapeutics
Alejandro M DopicoAditya K Singh

Abstract

Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR regulates the membrane physical state, microdomain formation and the activity of membrane-spanning proteins, including ion channels. Large conductance, voltage- and Ca²⁺-gated K⁺ (BK) channels link membrane potential to cell Ca²⁺ homeostasis. Thus, they control many physiological processes and participate in pathophysiological mechanisms leading to human disease. Because plasmalemma BK channels cluster in CLR-rich membrane microdomains, a major driving force for studying BK channel-CLR interactions is determining how membrane CLR controls the BK current phenotype, including its pharmacology, channel sorting, distribution, and role in cell physiology. Since both BK channels and CLR tissue levels play a pathophysiological role in human disease, identifying functional and structural aspects of the CLR-BK channel interaction may open new avenues for therapeutic intervention. Here, we review the studies documenting membrane CLR-BK channel interactions, dissecting out the many factors that determine the final BK current response to changes in membrane CLR content. We also summarize work in reductionist systems where recombinant BK protein is studied in ar...Continue Reading

References

Oct 26, 1976·Biochimica Et Biophysica Acta·R A Demel, B De Kruyff
Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
Nov 16, 1978·Biochimica Et Biophysica Acta·J H ChinD B Goldstein
Apr 25, 1986·Biochimica Et Biophysica Acta·J LechleiterR Gruener
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M Gruner
Jan 17, 1972·Biochimica Et Biophysica Acta·R A DemelL L van Deenen
Jan 1, 1983·CRC Critical Reviews in Biochemistry·K E Bloch
Oct 1, 1994·The Journal of General Physiology·J A Lundbaek, O S Andersen
Jan 1, 1995·The Journal of General Physiology·J J ArtR Fettiplace
Jan 1, 1993·Pharmacology & Therapeutics·M I Kotlikoff
Oct 1, 1995·Molecular and Chemical Neuropathology·F Omodeo-SaléP Palestini
Mar 26, 1996·Biochemistry·J A LundbaekO S Andersen
Jun 1, 1996·Journal of Bioenergetics and Biomembranes·G J KaczorowskiM L Garcia
Feb 1, 1997·Obstetrics and Gynecology·S S CraneR Artal
Sep 9, 1997·Biochemistry·G GimplF Fahrenholz
Jan 19, 1999·Annual Review of Cell and Developmental Biology·D A Brown, E London
Apr 1, 1999·Annual Review of Physiology·R Fettiplace, P A Fuchs
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·M Bravo-ZehnderA González
Mar 13, 2001·The Journal of Biological Chemistry·L TianM J Shipston
Oct 5, 2001·Trends in Pharmacological Sciences·R Schubert, M T Nelson
Oct 13, 2001·The Journal of Biological Chemistry·C M CrowderD F Covey
Nov 6, 2001·Progress in Lipid Research·Henna Ohvo-RekiläJ Peter Slotte

❮ Previous
Next ❯

Citations

Oct 25, 2012·Molecular Pharmacology·Jianxi LiuAlex M Dopico
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anna N BukiyaAlex M Dopico
Nov 15, 2014·International Journal of Molecular Sciences·Cheng DuManjiang Xie
Feb 14, 2016·Chemistry and Physics of Lipids·Yvonne Lange, Theodore L Steck
Dec 20, 2015·Reproductive Biology and Endocrinology : RB&E·Nicole S CarlsonK Joseph Hurt
Jun 20, 2014·Biochimica Et Biophysica Acta·Yujiao ZhangZhi Qi
Jul 22, 2015·Biochimica Et Biophysica Acta·Anna N BukiyaAvia Rosenhouse-Dantsker
Dec 3, 2014·Chemistry and Physics of Lipids·Tomasz Róg, Ilpo Vattulainen
Apr 5, 2015·Expert Opinion on Therapeutic Targets·Antonio LeoEmilio Russo
Apr 4, 2015·Biochimica Et Biophysica Acta·Francisco J TabernerAntonio Ferrer-Montiel
Oct 26, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Sibel BayrakAyşen Erdem
Nov 12, 2013·Biochimica Et Biophysica Acta·J A PovedaJ M González-Ros
Jun 25, 2013·Biochimica Et Biophysica Acta·Christian J BraunIndra Schroeder
Jan 21, 2014·European Journal of Medicinal Chemistry·Bianka Siewert, René Csuk
Feb 24, 2015·Frontiers in Physiology·Huanghe YangJianmin Cui
Sep 10, 2014·Frontiers in Physiology·Alex M Dopico, Anna N Bukiya
Jul 22, 2016·British Journal of Pharmacology·Louise E See HoeJason N Peart
Nov 2, 2016·The Journal of General Physiology·Guruprasad Kuntamallappanavar, Alex M Dopico
Apr 20, 2017·Journal of Lipid Research·Anna N Bukiya, Alejandro M Dopico
Jan 31, 2018·Pflügers Archiv : European journal of physiology·Jay S Naik, Benjimen R Walker
May 12, 2018·Pflügers Archiv : European journal of physiology·Alex M DopicoJonathan H Jaggar
Nov 14, 2018·Journal of Lipid Research·Anna N BukiyaAvia Rosenhouse-Dantsker
Mar 10, 2019·Fundamental & Clinical Pharmacology·Muhammed Fatih DoganKemal Gokhan Ulusoy
Feb 18, 2018·The Journal of General Physiology·Felix NeumaierToni Schneider
Nov 5, 2019·Aging·Ji Min KimByung-Joo Lee
Feb 19, 2017·The Journal of Biological Chemistry·Anna N BukiyaAvia Rosenhouse-Dantsker
Jan 14, 2021·The Journal of General Physiology·Laura-Marie WintersteinOliver Rauh
Feb 9, 2021·The Journal of Biological Chemistry·Anna N BukiyaAlex M Dopico
Feb 26, 2021·Inhalation Toxicology·Rebekah L Kendall, Andrij Holian
Apr 5, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Florina ZakanyZoltan Varga
May 6, 2021·International Journal of Molecular Sciences·Jisoo LeeSe-Young Choi
May 31, 2021·Biochemical Pharmacology·Miguel A LasunciónDiego Gómez-Coronado
Jun 29, 2021·Frontiers in Pharmacology·Sara T GranadosYolima P Torres
Jun 3, 2020·Current Vascular Pharmacology·Jorge A Carvajal, Joaquín I Oporto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.