Large-diameter deep anterior lamellar keratoplasty for keratoconus: visual and refractive outcomes

The British Journal of Ophthalmology
Ting HuangChao Hou

Abstract

To investigate the difference in clinical outcomes between large-diameter deep anterior lamellar keratoplasty (L-DALK) and standard DALK (S-DALK) for the treatment of keratoconus. 132 patients (132 eyes) from the Zhongshan Ophthalmic Center with a clinical diagnosis of keratoconus were enrolled. The participants were featured by the intolerance to rigid gas-permeable contact lenses or unsuccessful fitting of contact lenses. Using stratified blocked randomisation, eligible eyes were allocated into the L-DALK group or the S-DALK group (66 eyes, respectively). Postoperative uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refractive sphere, manifest cylinder and spherical equivalent refractive error were tested at 6, 12, 18 and 24 months after surgery. After surgery, the L-DALK group had better UCVA and BSCVA than the S-DALK group (p=0.000 and 0.021, respectively). At 24 months, mean BSCVA was 0.17±0.10 logarithm of the minimum angle of resolution (logMAR) (Snellen equivalent, 20/25) in the L-DALK group vs 0.22±0.10 logMAR (Snellen equivalent, 20/32) in the S-DALK group. Differences were observed between the L-DALK group and the S-DALK group in terms of refractive sphere (p=0.015), manifest cylinde...Continue Reading

References

Nov 1, 1992·Archives of Ophthalmology·J Sugar
Jul 26, 2002·American Journal of Ophthalmology·Jun ShimazakiKazuo Tsubota
Aug 7, 2002·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Anfitritis Thalasselis, Jorge Etchepareborda
Feb 7, 2006·American Journal of Ophthalmology·Rajesh Fogla, Prema Padmanabhan
Jul 11, 2006·Ophthalmology·Sudeep PramanikAyad A Farjo
Jan 30, 2007·American Journal of Ophthalmology·Navid ArdjomandDaniel F P Larkin
Jan 1, 2008·Ophthalmology·Philip D JaycockUNKNOWN UK Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists
Aug 30, 2008·American Journal of Ophthalmology·Irit BaharDavid S Rootman
Jul 11, 2009·American Journal of Ophthalmology·Daphne C Y HanDonald T H Tan
Feb 2, 2010·Cornea·Heather M Skeens, Edward J Holland
Feb 22, 2011·American Journal of Ophthalmology·Anil KubalogluYusuf Ozertürk
Jan 15, 2013·American Journal of Ophthalmology·Jiaxu HongJianjiang Xu

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Citations

Jan 19, 2017·Eye & Contact Lens·Elvin YildizEce Turan Vural
May 9, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias FuestJodhbir S Mehta
Feb 13, 2018·Journal of Ophthalmology·L Rico-Del-ViejoA Lorente-Velázquez
Sep 5, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Giuseppe GiannaccareVincenzo Scorcia
Oct 5, 2020·The British Journal of Ophthalmology·Angeli Christy YuMassimo Busin
May 16, 2020·Current Opinion in Ophthalmology·Angeli Christy YuMassimo Busin

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