PMID: 2500999May 29, 1989Paper

Large enhancement of excitatory postsynaptic potentials and currents by thyrotropin-releasing hormone (TRH) in frog spinal motoneurones

Brain Research
G LaceyE R Rhys-Maitland

Abstract

Frog spinal motoneurones were studied in vitro under voltage clamp conditions to examine the effect of the peptide thyrotropin-releasing hormone (TRH). TRH (50 microM) produced a small membrane depolarization, without obvious changes in the neuronal conductance or sensitivity to exogenously applied glutamate. These effects were seen regardless of the presence of 1 mM Mg2+ in the bathing solution. Low- and high-threshold excitatory postsynaptic potentials, induced by dorsal root stimulation, were enhanced by TRH. Under voltage clamp, TRH did not change the cell leak conductance while producing a considerable enhancement of polysynaptic current amplitude, particularly when recorded at a rather negative potential level. It is suggested that TRH might potentiate excitatory neurotransmission by facilitating presynaptic release of the excitatory neurotransmitter(s) onto motoneurones.

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Citations

Mar 19, 1991·European Journal of Pharmacology·M G GiovanniniA Nistri
Dec 18, 1992·Brain Research. Developmental Brain Research·P PoulatC Oliver
Mar 14, 2001·Glia·T Fernández-Agulló
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman

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