Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy

Scientific Reports
Alberto AstolfoAlessandro Olivo

Abstract

X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of 'conventional' absorption based x-ray systems. However, so far all XPCI implementations have suffered from one or more of the following limitations: low x-ray energies, small field of view (FOV) and long acquisition times. Those limitations relegated XPCI to a 'research-only' technique with an uncertain future in terms of large scale, high impact applications. We recently succeeded in designing, realizing and testing an XPCI system, which achieves significant steps toward simultaneously overcoming these limitations. Our system combines, for the first time, large FOV, high energy and fast scanning. Importantly, it is capable of providing high image quality at low x-ray doses, compatible with or even below those currently used in medical imaging. This extends the use of XPCI to areas which were unpractical or even inaccessible to previous XPCI solutions. We expect this will enable a long overdue translation into application fields such as security screening, industrial inspections and large FOV medical radiography - all with the inherent advantages of the XPCI multimodality.

References

Apr 1, 1995·Medical Physics·A Momose, J Fukuda
Dec 12, 1997·Physics in Medicine and Biology·D ChapmanD Sayers
Feb 7, 2001·Radiology·F ArfelliF Zanconati
Aug 16, 2003·European Radiology·Gisella GennaroMauro Gambaccini
Jan 2, 2004·Physics in Medicine and Biology·Miles N WernickCarol Muehleman
Aug 23, 2006·Journal of Synchrotron Radiation·Kentaro UesugiNaoto Yagi
May 5, 2007·The Review of Scientific Instruments·C KottlerC David
Jan 22, 2008·Nature Materials·F PfeifferC David
Apr 21, 2009·Academic Radiology·Christopher ParhamEtta D Pisano
Jun 3, 2009·The Review of Scientific Instruments·Tilman DonathChristian David
Nov 24, 2012·Physics in Medicine and Biology·Massimo MarenzanaAlessandro Olivo
Aug 14, 2013·Optics Express·Daniele PellicciaAlessia Cedola
Sep 7, 2013·Medical Physics·A OlivoR D Speller
Nov 14, 2013·Scientific Reports·M BechF Pfeiffer
May 16, 2014·Nature Communications·Zhentian WangMarco Stampanoni
Jun 2, 2014·The Review of Scientific Instruments·T P MillardA Olivo
Jun 7, 2014·Scientific Reports·T ThüringM Stampanoni
Jul 1, 2014·Optics Express·Paul C DiemozAlessandro Olivo
Mar 13, 2015·Scientific Reports·Rajmund MoksoHolger G Krapp
Jul 3, 2015·Journal of Synchrotron Radiation·Paul C DiemozAlessandro Olivo
Dec 3, 2015·EBioMedicine·A VelroyenF Pfeiffer
May 6, 2016·Scientific Reports·Marco EndrizziAlessandro Olivo
Jun 4, 2016·Journal of X-ray Science and Technology·J MeiserJ Mohr
Jul 29, 2016·Scientific Reports·Hongchang WangKawal Sawhney
Sep 8, 2016·Investigative Radiology·Katharina HellbachFelix G Meinel
Nov 29, 2016·Physics in Medicine and Biology·Paul C DiemozAlessandro Olivo

❮ Previous
Next ❯

Citations

Feb 8, 2019·Physics in Medicine and Biology·Veronika LudwigGisela Anton
Jan 13, 2018·Scientific Reports·Fulvia ArfelliRalf Hendrik Menk
Mar 14, 2019·Scientific Reports·Maria SeifertGisela Anton
Jun 25, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Alessandro Olivo

❮ Previous
Next ❯

Methods Mentioned

BETA
irradiates
x-ray imaging

Software Mentioned

XPCI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved