Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation.

PloS One
Ting-Jung WuChau-Ting Yeh

Abstract

Hepatitis B virus (HBV) associated end-stage liver diseases are the leading causes of liver transplantation (LT) in Taiwan. Relapse of hepatitis B occurs after LT, raising the risk of graft failure and reducing patient survival. Although several oral antiviral agents have been approved for anti-HBV treatment, lamivudine (LAM) remained to be the most widely used preventive regimen in Taiwan. While several clinical predictors have been identified for hepatitis B relapse, the predictive roles of the histopathological characteristics in liver explants as well as the genotypic features of the viruses in pre-LT serum samples have not been assessed. Between September 2002 and August 2009, 150 consecutive hepatitis B surface antigen (HBsAg) positive patients undergoing LT were included for outcome analysis following assessment of the clinicopathological and virological factors prior to LT. Kaplan-Meier analyses discovered that pre-operative LAM treatment ≤3 months; membranous distribution and higher expression of tissue HBsAg in liver explants; preoperative viral load ≥10(6) copies/ml; and presence of large fragment (>100 base pairs) pre-S deletion (LFpreSDel) correlated significantly with hepatitis B relapse. Multivariate Cox regressi...Continue Reading

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Citations

Aug 20, 2015·Hepatitis Monthly·Thomas MinaMahmoud Reza Pourkarim
Jan 17, 2015·World Journal of Gastroenterology : WJG·Shu ShenYong-Gang Wei
Feb 6, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kun-Ming ChanWei-Chen Lee

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SPSS

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