PMID: 9423821Jan 10, 1998Paper

Large granular lymphocyte leukemia with pure red cell aplasia in a renal transplant recipient

American Journal of Hematology
M MasudaH Mizoguchi

Abstract

Neoplastic disorders sometimes accompany a renal transplant. Herein, we report a large granular lymphocyte (LGL) leukemia patient with pure red cell aplasia (PRCA) after renal transplantation. A 36-year-old female was presented to our department with anemia in February 1996. She had undergone hemodialysis because of pregnancy in December 1981. She received a renal transplantation from her mother in April 1986. After the transplantation, she received cyclosporin A (CyA) at 2 mg/kg/day, mizoribine at 1 mg/kg/day, and methylprednisolone at 0.1 mg/kg/day for 8 years. In July 1995, her hemoglobin level dropped to 9.3 g/dl, and anemia developed gradually. In January 1996, her hemoglobin was 5.8 g/dl, and she was given a red blood cell transfusion. Laboratory findings were as follows: RBC 1.46 x 10(12)/L; hemoglobin 5.8 g/dl; hematocrit 17.8%; leucocytes 5.2 x 10(9)/L with 62.4% neutrophils, 34.1% lymphocytes, 2.6% monocytes; platelets 50.8 x 10(10)/L; reticulocytes 0.4%. Bone marrow aspirate smears and biopsy sections revealed normal myeloid and megakaryocyte differentiation with few erythroid precursors. The lymphocytes were of medium size with granules in the cytoplasm. More than 90% of lymphocytes were of the LGL type. Surface mar...Continue Reading

References

Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N C ZoumbosN S Young
Nov 1, 1984·Annals of Internal Medicine·D J CohenT B Strom
Jun 27, 1995·Transplantation·S B GayaP D Mason
Aug 12, 1995·Lancet·N J LondonJ P Lodge
Jan 27, 1995·Transplantation·I Penn, G Porat
Mar 1, 1996·Annals of Hematology·Y L KwongT K Chan
Apr 1, 1997·American Journal of Hematology·M MasudaH Mizoguchi

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Citations

May 19, 2007·American Journal of Clinical Pathology·Dennis P O'Malley
May 19, 2007·American Journal of Clinical Pathology·Steven H Swerdlow
Jul 17, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sabine Nann-RüttiAlicia Rovó
Jan 20, 2010·Annals of Hematology·Yok-Lam KwongEric W C Tse
Jul 5, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Rumi MinamiEiichi Suematsu
Nov 9, 2017·Oncotarget·Zhi-Yuan QiuJian-Yong Li
Jun 30, 2019·International Journal of Hematology·Gaetano AlfanoGianni Cappelli

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