PMID: 3711381May 1, 1986

Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil

Journal of the American Academy of Dermatology
C M Parker, C W Hanke


Keratoacanthoma is a benign tumor; however, it may cause massive destruction of normal tissue during its rapid growth phase. Intralesional 5-fluorouracil (5-FU) has been shown to be an effective treatment for keratoacanthoma. We have successfully treated five patients with large keratoacanthomas in difficult locations. There have been no recurrences during follow-up periods ranging from 18 to 45 months. Intralesional 5-FU may be ineffective for keratoacanthomas that are not rapidly proliferating.


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