Large lesions in the pre-Bötzinger complex area eliminate eupneic respiratory rhythm in awake goats

Journal of Applied Physiology
J M WenningerH V Forster

Abstract

In awake goats, 29% bilateral destruction of neurokinin-1 receptor-expressing neurons in the pre-Bötzinger complex (pre-BötzC) area with saporin conjugated to substance P results in transient disruptions of the normal pattern of eupneic respiratory muscle activation (Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah T, Davis S, and Forster HV. J Appl Physiol 97: 1620-1628, 2004). Therefore, the purpose of these studies was to determine whether large or total lesioning in the pre-BötzC area of goats would eliminate phasic diaphragm activity and the eupneic breathing pattern. In awake goats that already had 29% bilateral destruction of neurokinin-1 receptor-expressing neurons in the pre-BötzC area, bilateral ibotenic acid (10 microl, 50 mM) injection into the pre-BötzC area resulted in a tachypneic hyperpnea that reached a maximum (132 +/- 10.1 breaths/min) approximately 30-90 min after bilateral injection. Thereafter, breathing frequency declined, central apneas resulted in arterial hypoxemia (arterial Po2 approximately 40 Torr) and hypercapnia (arterial Pco2 approximately 60 Torr), and, 11 +/- 3 min after the peak tachypnea, respiratory failure was followed by cardiac arrest in three airway-intact goats. H...Continue Reading

References

Oct 1, 1988·Journal of Applied Physiology·E E NattieW M St John
Mar 15, 1996·The Journal of Physiology·N Koshiya, P G Guyenet
Nov 1, 1996·Journal of Applied Physiology·W M St John
Nov 10, 1998·Journal of the Autonomic Nervous System·J H HsiehC Y Chai
Oct 12, 1999·The Journal of Physiology·R St-Jacques, W M St-John
Feb 25, 2003·Annual Review of Neuroscience·Jack L FeldmanEugene E Nattie
Mar 21, 1923·The Journal of Physiology·T Lumsden
Oct 22, 1923·The Journal of Physiology·T Lumsden

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Citations

May 26, 2005·Respiratory Physiology & Neurobiology·Michael S Hedrick
Feb 24, 2006·Nature Reviews. Neuroscience·Jack L Feldman, Christopher A Del Negro
Aug 23, 2011·Integrative and Comparative Biology·Henner KochJan-Marino Ramirez
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Walter M St John
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Fernando Peña
Nov 15, 2008·Journal of Applied Physiology·K L KrauseB Qian
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henner KochJan-Marino Ramirez
Nov 6, 2012·Annual Review of Physiology·Jack L FeldmanPaul A Gray
Nov 19, 2005·The Journal of Physiology·Wiktor A Janczewski, Jack L Feldman
May 27, 2015·The Journal of Physiology·Zaki AlsahafiSilvia Pagliardini
Jan 30, 2013·Respiratory Physiology & Neurobiology·Gregory D Funk, John J Greer
Aug 17, 2010·Respiratory Physiology & Neurobiology·Angélique Bordey
Apr 24, 2010·Respiratory Physiology & Neurobiology·Nicholas M Mellen
May 2, 2009·Respiratory Physiology & Neurobiology·Klaus Ballanyi, Araya Ruangkittisakul
Jul 8, 2008·Respiratory Physiology & Neurobiology·Atsushi Doi, Jan-Marino Ramirez
Jun 6, 2006·Respiratory Physiology & Neurobiology·Richard J A WilsonJohn E Remmers
Jun 28, 2005·Respiratory Physiology & Neurobiology·Julie M WenningerGerald E Bisgard
Dec 4, 2012·Respiratory Physiology & Neurobiology·Natalia Toporikova, Robert J Butera
Sep 14, 2010·Respiratory Physiology & Neurobiology·Araya RuangkittisakulKlaus Ballanyi
Sep 30, 2014·Respiratory Physiology & Neurobiology·Clarissa MuereHubert V Forster
May 2, 2018·Annual Review of Neuroscience·Jan-Marino Ramirez, Nathan A Baertsch
Aug 16, 2018·Physiology·Jan-Marino Ramirez, Nathan Baertsch
Oct 12, 2018·The Journal of General Physiology·Tadashi YamanishiJeffrey C Smith
Mar 30, 2010·The European Journal of Neuroscience·Faiza Ben-Mabrouk, Andrew K Tryba
Feb 3, 2007·Journal of Applied Physiology·Jan-Marino Ramirez, Alfredo Garcia
Apr 18, 2019·Physiological Reports·Nicholas J BurgraffHubert V Forster
May 3, 2014·Journal of Applied Physiology·Justin Robert MillerHubert V Forster
Jul 22, 2014·The European Journal of Neuroscience·Srinivasan TupalPaul A Gray
Jan 6, 2015·The Journal of Physiology·Jack L Feldman, Kaiwen Kam
Jan 6, 2015·The Journal of Physiology·Henner KochJan-Marino Ramirez

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