PMID: 11604068Oct 18, 2001Paper

Large-mutation spectra induced at hemizygous loci by low-LET radiation: evidence for intrachromosomal proximity effects

Radiation Research
Sylvain V CostesB Fouladi

Abstract

A mathematical model is used to analyze mutant spectra for large mutations induced by low-LET radiation. The model equations are based mainly on two-break misrejoining that leads to deletions or translocations. It is assumed, as a working hypothesis, that the initial damage induced by low-LET radiation is located randomly in the genome. Specifically, we analyzed data for two hemizygous loci: CD59- mutants, mainly very large-scale deletions (>3 Mbp), in human-hamster hybrid cells, and data from the literature on those HPRT- mutants which involve at least deletion of the whole gene, and often of additional flanking markers (approximately 50-kbp to approximately 4.4-Mbp deletions). For five data sets, we estimated f, the probability that two given breaks on the same chromosome will misrejoin to make a deletion, as a function of the separation between the breaks. We found that f is larger for nearby breaks than for breaks that are more widely separated; i.e., there is a "proximity effect". For acute irradiation, the values of f determined from the data are consistent with the corresponding break misrejoining parameters found previously in quantitative modeling of chromosome aberrations. The value of f was somewhat smaller for protr...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C WaldrenT T Puck
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C JonesD W Lehman
Jan 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J M BoyleP J Smith
Nov 1, 1989·Somatic Cell and Molecular Genetics·T GlaserC Jones
Apr 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M Frankenberg-Schwager
Jul 1, 1987·Somatic Cell and Molecular Genetics·T T Puck, C A Waldren
Jul 1, 1987·Somatic Cell and Molecular Genetics·C A Waldren, T T Puck
Jun 1, 1982·Mutation Research·H L Liber, W G Thilly
Sep 1, 1995·International Journal of Radiation Biology·P Virsik-PeuckertD Mehmel
Mar 1, 1994·Carcinogenesis·S L NelsonA J Grosovsky
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Morris, J Thacker
Oct 1, 1996·International Journal of Radiation Biology·D J BrennerR K Sachs
Jul 1, 1996·Somatic Cell and Molecular Genetics·N D Costa, J Thacker
Jun 20, 1997·The Journal of Biological Chemistry·N NakamuraT Kinoshita
Oct 29, 1997·International Journal of Radiation Biology·R K SachsD J Brenner
Aug 1, 1997·Journal of Biochemistry·T KinoshitaJ Takeda
Sep 5, 1998·Mutation Research·J R Savage
Jan 15, 1999·Journal of Molecular Biology·C MünkelJ Langowski
Mar 11, 1999·International Journal of Radiation Biology·K L JohnsonC R Geard
Mar 15, 2000·International Journal of Radiation Biology·R K SachsL R Hlatky
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·M M Vilenchik, A G Knudson
Dec 1, 2000·International Journal of Radiation Biology·F A CucinottaD T Goodhead

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Citations

May 4, 2006·Radiation Research·Sylvain V CostesMary Helen Barcellos-Hoff
Jun 28, 2016·Life Sciences in Space Research·Deepa M SridharanJanice M Pluth
Jun 23, 2016·Radiation Research·A C HeuskinS V Costes
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Teresa NeumaierSylvain V Costes
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lynn HlatkyMichael N Cornforth
Jul 9, 2005·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Carley D RossMichael H Fox
Oct 21, 2020·Nucleic Acids Research·Daniel C BerriosSylvain V Costes

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