Large particle hyaluronic Acid gel for the treatment of lower eyelid retraction associated with radiation-induced lipoatrophy

Ophthalmic Plastic and Reconstructive Surgery
Jeffrey L PeckinpaughRobert N Tower

Abstract

A 42-year-old female with a remote history of a left maxillary sinus tumor treated with excision and radiation therapy was referred for dry eye symptoms. Ophthalmic examination revealed left-sided exposure keratopathy, lagophthalmos, lower eyelid retraction, and fat atrophy of inferior periorbital tissue with associated hollowing. Large particle hyaluronic acid gel was injected to expand and reinforce the lower eyelid. After treatment, there was significant improvement in lagophthalmos, inferior scleral show, and periorbital hollowing. Excellent symmetry with the fellow eye was achieved. The patient reported markedly reduced dry eye symptoms. No adverse side effects were observed. The use of large particle hyaluronic acid gel shows promise as a novel nonsurgical therapy in the management of lower eyelid retraction associated with radiation-induced lipoatrophy. Additionally, large particle hyaluronic acid gel may provide better soft tissue expansion and retention than small particle hyaluronic acid gel, increasing the longevity of treatment.

References

Jul 22, 2004·Ophthalmic Plastic and Reconstructive Surgery·Charles N S SoparkarJamie Tschen
May 10, 2007·Acta Ophthalmologica Scandinavica·Shane R DurkinDinesh Selva
Sep 21, 2007·Ophthalmic Plastic and Reconstructive Surgery·Robert A GoldbergJohn D McCann

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Citations

Aug 11, 2017·The British Journal of Ophthalmology·Ana Beatriz Diniz GrisoliaCésar Augusto Briceño
Nov 18, 2017·The British Journal of Ophthalmology·Petrina TanRaman Malhotra
May 13, 2014·Ophthalmic Plastic and Reconstructive Surgery·Thao Phuong LeA J Amadi
Mar 21, 2021·International Ophthalmology Clinics·Sanja G CypenJeremiah P Tao
Aug 12, 2020·Journal of the American Academy of Dermatology·Anthony M RossiMario E Lacouture

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