Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy

Nanoscale
Takahito NakamuraYukio Nagasaki

Abstract

A biocompatible photothermal nanomedicine based on a PEGylated nanogel containing gold nanoparticles (GNPs) in a cross-linked network core of stimuli-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (PEAMA) gel for cancer photothermal therapy (PTT) was prepared through the reduction of Au(iii) ions without any reducing agents. The influence of the reduction conditions, such as pH, temperature, and N/Au ratio (molar ratio of the amino groups in the PEGylated nanogel to the Au(iii) ions), on the formation of the GNPs in the stimuli-responsive PEAMA gel core (reducing environment) was also studied. Note that the PEGylated nanogel containing GNPs prepared at pH 6, 60 degrees C and N/Au = 1 (PEGylated GNG (1)) was found to have the highest GNP-loading capacity with a diameter of about 8 nm, as observed by TEM; viz., about 27 GNPs formed in a single PEAMA gel core. PEGylated GNG (1) showed a remarkable photothermal efficacy (DeltaT = 7.7 degrees C) under irradiation with Ar ion (Ar(+)) laser (514.5 nm) at a fluence of 39 W cm(-2) for 6 min (14 kJ cm(-2)). Note that PEGylated GNG (1) showed non-cytotoxicity in the absence of irradiation with Ar(+) laser (480 microg mL(-1): > 90% cell viability), whereas pronounced cytotoxicity ...Continue Reading

References

Jan 1, 1990·Lasers in Surgery and Medicine·T J DoughertyT S Mang
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Apr 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·M R Hamblin, E L Newman
Aug 25, 1999·Drugs & Aging·J S McCaughan
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Oct 28, 2004·Journal of the American Chemical Society·Ayush VermaVincent M Rotello
Jan 15, 2005·Otolaryngologic Clinics of North America·Ivan H El-SayedFrank Civantos
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
Jan 26, 2006·Journal of the American Chemical Society·Rui HongVincent M Rotello
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Mar 15, 2006·Biomacromolecules·Peisheng XuYouqing Shen
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takuro NiidomeYasuro Niidome
Oct 16, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristianne J F RijckenCornelus F van Nostrum
Nov 14, 2008·Journal of the American Chemical Society·Juan D HenaoHarold H Kung
Jan 13, 2009·Bioconjugate Chemistry·Takahito KawanoTakuro Niidome
Mar 1, 2005·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata

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Citations

Dec 9, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D M EckmannV R Muzykantov
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Hui ZhangGuangxi Zhai
Sep 16, 2015·Soft Matter·B Sierra-Martin, A Fernandez-Barbero
Oct 20, 2011·Advanced Materials·María Vallet-Regí, Eduardo Ruiz-Hernández
Nov 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kruti S SoniTatiana K Bronich
Dec 2, 2011·Chemical Society Reviews·Lev Dykman, Nikolai Khlebtsov
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Marjan GhorbaniAli Akbar Entezami
Jul 23, 2016·Advanced Healthcare Materials·Yu-Jia LiChih-Ching Huang
Mar 7, 2017·Biochemistry. Biokhimii︠a︡·L A Dykman, N G Khlebtsov
Oct 28, 2015·Chemical Society Reviews·Maria MolinaMarcelo Calderón
Sep 30, 2015·Gels·Marleen HäringDavid Díaz Díaz
Feb 10, 2019·Pharmaceutics·Parisa EslamiStefano Fedeli
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amjad Ali KhanArshad Husain Rahmani
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola MicaleAntonio Speciale
Sep 22, 2021·Journal of Biomaterials Science. Polymer Edition·Balaji MaddiboyinaVikas Jhawat

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