Large Porous Hollow Particles: Lightweight Champions of Pulmonary Drug Delivery

Current Pharmaceutical Design
Sachin Gharse, Jennifer Fiegel

Abstract

The deep lungs provide an efficient pathway for drugs to transport into the systemic circulation, as the extremely large surface area and thin epithelial membrane enable rapid drug transport to the blood stream. To penetrate into the deep lungs, aerosol particles with aerodynamic diameters of 1-3 µm are optimal. Large porous hollow particles (LPHPs) can achieve this aerodynamic size range through enhanced porosity within the particles (typically < 0.4 g/cm(3)), which aerodynamically balances the large particle size (> 5 µm, up to 30 µm). The physical properties of these particles provide some key advantages compared to their small, nonporous counterparts through enhanced dispersibility, efficient deep lung deposition, and avoidance of phagocytic clearance. This review highlights the potential of LPHPs in pulmonary delivery of systemic drugs, with a focus on their critical attributes and key formulation aspects. In addition, three examples of LPHPs under development are presented to emphasize the potential of this technology to treat systemic diseases.

Citations

Nov 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara YazdiDavid Putnam
Nov 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ling DingDavid Oupický
Apr 14, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Susmita AryalJaehong Key
Apr 5, 2021·International Journal of Pharmaceutics·Shadi YaqoubiHamed Hamishehkar
May 5, 2020·ACS Applied Materials & Interfaces·Cristina Fernández-PazPatricia Horcajada

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