Large reduction in the number of galanin-immunoreactive cells in pancreatic islets of diabetic rats

Journal of Neuroendocrinology
E Adeghate, A S Ponery

Abstract

Although galanin has been shown to be present in pancreatic islet cells, there is no literature available on the pattern of distribution and the effect of galanin in the pancreas of diabetic animals or human models. The aim of this study was to examine whether galanin immunoreactivity changes after the onset of diabetes mellitus in the rat model. The present study used immunohistochemical techniques to examine the pattern of distribution of galanin-like immunoreactive cells in the pancreas of rats with streptozotocin-induced diabetes. The effect of galanin on insulin secretion from intact rat pancreatic tissue fragments was also investigated using a radioimmunoassay technique. Numerous galanin-like immunoreactive cells were observed in both the peripheral and central regions of the islet of Langerhans of normal rat pancreas. By contrast, the islets of diabetic rat pancreas contained significantly (P < 0.0001) fewer galanin-like immunoreactive cells than nondiabetic rats. Galanin was colocalized with insulin in the islets of normal and diabetic rats. Galanin had an inhibitory effect on insulin secretion from the isolated pancreatic tissue fragments of normal and diabetic rats at all concentrations (10(-12) to 10(-6) M) employed....Continue Reading

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Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Guanghua TangMeisheng Jiang
Feb 7, 2014·The Journal of Endocrinology·Le BuShen Qu
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sümeyra NergizAli Rıza Odabaşı
Feb 5, 2013·Life Sciences·Penghua FangMingyi Shi
Oct 27, 2015·Histochemistry and Cell Biology·P PodlaszJ Kaleczyc
Nov 21, 2015·Experimental Gerontology·Penghua FangZhenwen Zhang
Jan 19, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M BhandariG T P Saccone
Nov 7, 2015·Neuroscience and Biobehavioral Reviews·Penghua FangZhenwen Zhang
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S G BarretoG T P Saccone
Apr 26, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Nicholas AngelopoulosGeorge Tolis
Aug 9, 2015·Mechanisms of Ageing and Development·Zhenwen ZhangPing Bo
May 9, 2015·Acta histochemica·Izabela Janiuk, Krzysztof Młynek
Aug 23, 2012·General and Comparative Endocrinology·Penghua FangPing Bo
Aug 17, 2018·Cell and Tissue Research·Ernest AdeghateErnest A Adeghate
Jun 6, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Savio G BarretoGino T P Saccone

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