Large-scale analysis of iliopsoas muscle volumes in the UK Biobank.

Scientific Reports
Julie FitzpatrickBrandon Whitcher

Abstract

Psoas muscle measurements are frequently used as markers of sarcopenia and predictors of health. Manually measured cross-sectional areas are most commonly used, but there is a lack of consistency regarding the position of the measurement and manual annotations are not practical for large population studies. We have developed a fully automated method to measure iliopsoas muscle volume (comprised of the psoas and iliacus muscles) using a convolutional neural network. Magnetic resonance images were obtained from the UK Biobank for 5000 participants, balanced for age, gender and BMI. Ninety manual annotations were available for model training and validation. The model showed excellent performance against out-of-sample data (average dice score coefficient of 0.9046 ± 0.0058 for six-fold cross-validation). Iliopsoas muscle volumes were successfully measured in all 5000 participants. Iliopsoas volume was greater in male compared with female subjects. There was a small but significant asymmetry between left and right iliopsoas muscle volumes. We also found that iliopsoas volume was significantly related to height, BMI and age, and that there was an acceleration in muscle volume decrease in men with age. Our method provides a robust tec...Continue Reading

References

Jun 1, 1994·Archives of Physical Medicine and Rehabilitation·J G ReidD J Pearsall
May 1, 1997·The Journal of Nutrition·I H Rosenberg
May 7, 1998·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D Gallagher, S B Heymsfield
May 25, 1999·Journal of Anatomy·P HansonE B Simonsen
Jul 25, 2000·Journal of Applied Physiology·I JanssenR Ross
Jul 11, 2007·Spine·Julie A HidesCarolyn A Richardson
Oct 17, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marina MourtzakisVickie E Baracos
May 29, 2009·British Journal of Sports Medicine·S StewartJ Hides
Jan 11, 2011·Journal of Vascular Surgery·Jay Soong-Jin LeeUNKNOWN Michigan Analytic Morphomics Group (MAMG)
Apr 17, 2013·International Journal of Computer Assisted Radiology and Surgery·Marco NoldenIvo Wolf
Mar 13, 2014·Journal of Hepatology·François DurandDominique Valla
Oct 21, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K I JonesJ P Williams
Nov 13, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Vicente ValeroTimothy M Pawlik
Dec 3, 2014·Annals of Vascular Surgery·Sarah Swanson, Robert B Patterson
May 1, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Neda AminiTimothy M Pawlik
Feb 1, 2014·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·L EbbelingD N Holena
Mar 21, 2016·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Glen R MorrellSrinivasan Beddhu
Sep 24, 2016·The Annals of Thoracic Surgery·Remi HervochonMarco Alifano
Oct 30, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L M DrudiJ Afilalo
Jul 5, 2017·Journal of Cachexia, Sarcopenia and Muscle·Vickie E Baracos
Dec 17, 2018·Zeitschrift für medizinische Physik·Alexander Selvikvåg Lundervold, Arvid Lundervold
Jan 11, 2019·Scientific Reports·Aldenor G SantosJailson B de Andrade
Apr 3, 2019·Radiological Physics and Technology·Fumio HashimotoSadahiko Nishizawa
Sep 13, 2019·IEEE Transactions on Medical Imaging·Yuta HiasaYoshinobu Sato
Sep 17, 2019·Medicine and Science in Sports and Exercise·Alexandre MaltaisJean-Pierre Després
Nov 5, 2019·Journal of Vascular and Interventional Radiology : JVIR·Timothy C HuberLuke R Wilkins

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Software Mentioned

MITK
TensorFlow
R software environment for statistical computing and graphics
Keras

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