Large-scale chromatin organisation in interphase, mitosis and meiosis

The Biochemical Journal
Isobel A MacGregorNick Gilbert

Abstract

The spatial configuration of chromatin is fundamental to ensure any given cell can fulfil its functional duties, from gene expression to specialised cellular division. Significant technological innovations have facilitated further insights into the structure, function and regulation of three-dimensional chromatin organisation. To date, the vast majority of investigations into chromatin organisation have been conducted in interphase and mitotic cells leaving meiotic chromatin relatively unexplored. In combination, cytological and genome-wide contact frequency analyses in mammalian germ cells have recently demonstrated that large-scale chromatin structures in meiotic prophase I are reminiscent of the sequential loop arrays found in mitotic cells, although interphase-like segmentation of transcriptionally active and inactive regions are also evident along the length of chromosomes. Here, we discuss the similarities and differences of such large-scale chromatin architecture, between interphase, mitotic and meiotic cells, as well as their functional relevance and the proposed modulatory mechanisms which underlie them.

References

Aug 1, 1979·Cell·M P Marsden, U K Laemmli
Nov 1, 1977·Cell·J R Paulson, U K Laemmli
Nov 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P B Møens, R E Pearlman
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P SorianoR Jaenisch
Jan 1, 1983·The Journal of Cell Biology·W C Earnshaw, U K Laemmli
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·H H HengP B Moens
Feb 26, 2000·Annual Review of Genetics·D Zickler, N Kleckner
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·H Scherthan
Nov 3, 2001·Genome Research·J PerryA Ashworth
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael G Poirier, John F Marko
Dec 5, 2002·Genes & Development·Sinisa DovatStephen T Smale
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Joan-Ramon Daban
Aug 9, 2003·Science·Scott L Page, R Scott Hawley
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Derek Jantz, Jeremy M Berg
Oct 30, 2004·Genesis : the Journal of Genetics and Development·Laura A BannisterJohn C Schimenti
Nov 24, 2004·The Journal of Cell Biology·Raymond C ChanBarbara J Meyer
Mar 2, 2005·PLoS Biology·Thomas Lenormand, Julien Dutheil
Jun 7, 2005·Developmental Cell·Huiling XuMichael J McKay
Jul 14, 2006·Nature·Matthew J Neale, Scott Keeney
May 1, 2007·Current Opinion in Cell Biology·Edith Heard, Wendy Bickmore
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Frédéric Baudat, Bernard de Massy
Oct 30, 2007·Trends in Genetics : TIG·Petko M PetkovKenneth Paigen
Jan 9, 2008·The Journal of Cell Biology·Ivana NovakChrister Höög
Feb 1, 2008·Nature·Kerstin S WendtJan-Michael Peters
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Noah DephoureSteven P Gygi
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mikhail EltsovJacques Dubochet
Aug 29, 2009·BMC Molecular Biology·Peter HegerEinhard Schierenberg
Oct 21, 2009·The Journal of Cell Biology·Caroline AdelfalkRolf Jessberger
Nov 6, 2009·Annual Review of Genetics·Kim Nasmyth, Christian H Haering

❮ Previous
Next ❯

Citations

Sep 24, 2020·Biochemical Society Transactions·Roger Solé-Soler, Jordi Torres-Rosell
Apr 11, 2021·Seminars in Cell & Developmental Biology·James R PaulsonWilliam C Earnshaw
Aug 11, 2021·Nature Structural & Molecular Biology·James M DunceOwen R Davies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Cell Biology
A S BelmontT Tumbar
Critical Reviews in Biochemistry and Molecular Biology
Marlies E Oomen, Job Dekker
Journal of Genetics and Genomics = Yi Chuan Xue Bao
James H CrichtonIan R Adams
© 2021 Meta ULC. All rights reserved