Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Fumihiko UrabeTakahiro Ochiya

Abstract

The high false-positive rate of prostate-specific antigen (PSA) may lead to unnecessary prostate biopsies. Therefore, the United States Preventive Services Task Force recommends that decisions regarding PSA-based screening of prostate cancer should be made with caution in men ages 55-69 years, and that men ≥70 years should not undergo PSA screening. Here, we investigated the potential of serum miRNAs as an accurate diagnostic method in patients with suspected prostate cancer. Serum samples of 809 patients with prostate cancer, 241 negative prostate biopsies, and 500 patients with other cancer types were obtained from the National Cancer Center, Japan. Forty-one healthy control samples were obtained from two other hospitals in Japan. Comprehensive microarray analysis was performed for all samples. Samples were divided into three sets. Candidate miRNAs for prostate cancer detection were identified in the discovery set (n = 123). A diagnostic model was constructed using combinations of candidate miRNAs in the training set (n = 484). The performance of the diagnostic model was evaluated in the validation set (n = 484). In the discovery set, 18 candidate miRNAs were identified. A robust diagnostic model was constructed using the com...Continue Reading

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Citations

Oct 3, 2019·Expert Review of Molecular Diagnostics·Emmy BoerrigterJack A Schalken
Feb 28, 2020·Medicina·Vlad Cristian MunteanuIoan Coman
May 15, 2020·The Keio Journal of Medicine·Juntaro Matsuzaki, Takahiro Ochiya
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Jan 17, 2021·Seminars in Cancer Biology·Kurataka Otsuka, Takahiro Ochiya
Mar 21, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seiichiro AbeTakahiro Ochiya
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Jul 3, 2021·Cancers·Cora Palanca-BallesterAlfonso Calvo
Aug 5, 2021·Lab on a Chip·Chi-Ju KimKenneth J Pienta

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